UBE2K

GENE INFORMATION

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Gene name

UBE2K (HGNC Symbol)

Synonyms

HIP2, HYPG, UBC1

Description

ubiquitin-conjugating enzyme E2K (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

4 (Chromosome progress)

Cytoband

p14

Chromosome location (bp)

39699664 - 39784412

Ensembl

ENSG00000078140 (version 73.37)

Entrez gene

3093

UniProt

P61086 (UniProt - Evidence at protein level)

neXtProt

NX_P61086

Antibodypedia

UBE2K antibodies
 

PROTEIN VIEW

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UBE2K-001
 
UBE2K-004
 
UBE2K-005
 
UBE2K-006
 
UBE2K-007
 
UBE2K-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UBE2K-001 ENSP00000261427
ENST00000261427
P61086
Show all »
Show » Show » 200 22.4 No 0
UBE2K-004 ENSP00000425301
ENST00000510934
D6RDM7
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Show » 123 14 No 0
UBE2K-005 ENSP00000421203
ENST00000503368
P61086
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Show » Show » 149 16.6 No 0
UBE2K-006 ENSP00000390483
ENST00000445950
P61086
Show all »
Show » Show » 157 17.4 No 0
UBE2K-007 ENSP00000421422
ENST00000510719
D6RFX1
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44 4.8 No 0
UBE2K-201 ENSP00000295963
ENST00000295963
B4DIZ2
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Show » 139 15.8 No 0