SMARCA2

GENERAL INFORMATION

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Gene name

SMARCA2

Gene description

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

Protein class

Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

16
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General nuclear expression.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA029981 , CAB037276
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

SMARCA2 (HGNC Symbol)

Synonyms

BAF190, BRM, hBRM, hSNF2a, SNF2, SNF2L2, SNF2LA, Sth1p, SWI2

Description

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism. [provided by RefSeq, Jan 2014]

Chromosome

9

Cytoband

p24.3

Chromosome location (bp)

2015219 - 2193624

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000080503 (version 78.38)

Entrez gene

6595

UniProt

P51531 (UniProt - Evidence at protein level)

neXtProt

NX_P51531

Antibodypedia

SMARCA2 antibodies


PROTEIN BROWSER

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ENST00000302401
 
ENST00000324954
 
ENST00000349721
 
ENST00000357248
 
ENST00000382183
 
ENST00000382185
 
ENST00000382186
 
ENST00000382194
 
ENST00000382203
 
ENST00000416751
 
ENST00000417599
 
ENST00000423555
 
ENST00000439732
 
ENST00000450198
 
ENST00000452193
 
ENST00000457226
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SMARCA2-001 ENSP00000305411
ENST00000302401
B1ALF6
Show all »
Show » Show » 278 32 Yes 0
SMARCA2-003 ENSP00000371638
ENST00000382203
P51531
Show all »
Show » Show » 1590 181.3 No 0
SMARCA2-004 ENSP00000371629
ENST00000382194
P51531
Show all »
Show » Show » 1572 179.3 No 0
SMARCA2-005 ENSP00000409398
ENST00000439732
F6RS74
Show all »
Show » 155 15.5 No 0
SMARCA2-006 ENSP00000415218
ENST00000457226
F6RS74
Show all »
Show » 66 6.3 No 0
SMARCA2-008 ENSP00000392081
ENST00000450198
F6VDE0
Show all »
Show » Show » 559 61.9 No 0
SMARCA2-009 ENSP00000371620
ENST00000382185
B1ALG1
Show all »
Show » Show » 236 27.5 No 0
SMARCA2-010 ENSP00000371621
ENST00000382186
B1ALG2
Show all »
Show » Show » 254 29.5 No 0
SMARCA2-011 ENSP00000401096
ENST00000452193
Show » Show » 171 20 No 0
SMARCA2-012 ENSP00000387486
ENST00000417599
F6XG14
Show all »
Show » Show » 271 31.3 Yes 0
SMARCA2-013 ENSP00000371618
ENST00000382183
B1ALG1
Show all »
Show » Show » 236 27.5 No 0
SMARCA2-014 ENSP00000413057
ENST00000423555
F6XE55
Show all »
Show » Show » 153 17.7 Yes 0
SMARCA2-015 ENSP00000412242
ENST00000416751
F6UH26
Show all »
Show » Show » 177 20.9 No 0
SMARCA2-201 ENSP00000324770
ENST00000324954
B1ALG1
Show all »
Show » Show » 248 28.9 No 0
SMARCA2-202 ENSP00000265773
ENST00000349721
P51531
Show all »
Show » Show » 1590 181.3 No 0
SMARCA2-203 ENSP00000349788
ENST00000357248
P51531
Show all »
Show » Show » 1572 179.3 No 0