CPB2

GENE INFORMATION

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Gene name

CPB2 (HGNC Symbol)

Synonyms

CPU, PCPB, TAFI

Description

carboxypeptidase B2 (plasma) (HGNC Symbol)

Entrez gene summary

Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Chromosome

13 (Chromosome progress)

Cytoband

q14.13

Chromosome location (bp)

46627321 - 46679211

Ensembl

ENSG00000080618 (version 73.37)

Entrez gene

1361

UniProt

Q96IY4 (UniProt - Evidence at protein level)

neXtProt

NX_Q96IY4

Antibodypedia

CPB2 antibodies
 

PROTEIN VIEW

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CPB2-001
 
CPB2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CPB2-001 ENSP00000181383
ENST00000181383
Q96IY4
Show all »
Show » Show » 423 48.4 Yes 0
CPB2-201 ENSP00000400714
ENST00000439329
Q96IY4
Show all »
Show » Show » 360 40.9 Yes 0