KCNN2

GENE INFORMATION

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Gene name

KCNN2 (HGNC Symbol)

Synonyms

hSK2, KCa2.2

Description

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 (HGNC Symbol)

Entrez gene summary

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

Chromosome

5 (Chromosome progress)

Cytoband

q22.3

Chromosome location (bp)

113696642 - 113832337

Ensembl

ENSG00000080709 (version 73.37)

Entrez gene

3781

UniProt

Q9H2S1 (UniProt - Evidence at transcript level)

neXtProt

NX_Q9H2S1

Antibodypedia

KCNN2 antibodies
 

PROTEIN VIEW

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KCNN2-001
 
KCNN2-002
 
KCNN2-004
 
KCNN2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KCNN2-001 ENSP00000427120
ENST00000512097
Show » Show » 579 63.8 No 7
KCNN2-002 ENSP00000421439
ENST00000503706
Q9H2S1
Show all »
Show » Show » 231 26.3 No 1
KCNN2-004 ENSP00000421095
ENST00000505491
D6RGY7
Show all »
Show » Show » 95 10.6 No 1
KCNN2-201 ENSP00000264773
ENST00000264773
Q9H2S1
Show all »
Show » Show » 579 63.8 No 7