The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right). The lenght of the bar represents the number of patient samples analysed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the immunohistochemistry validation score for that antibody.
Most malignancies showed weak to moderate cytoplasmic staining. Several gastric cancers as well as cases of cervical, prostate and ovarian cancers showed strong immunoreactivity. A majority of malignant lymphomas, lung, skin, pancreatic and liver cancers were negative.
Most cancers displayed moderate cytoplasmic positivity with a granular pattern. Several colorectal cancers and cervical squamous cell carcinomas along with a few ovarian cancers and malignant carcinoids were strongly stained. Several malignant lymphomas and renal cancers were weakly stained or negative.
Validation
Two (or more) antibodies yielding similar staining patterns which are consistent with available gene/protein characterization data
Two (or more) antibodies yielding similar staining patterns which are consistent with available gene/protein characterization data
