AFP

GENERAL INFORMATION

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Gene name

AFP

Gene description

Alpha-fetoprotein

Protein class

Cancer-related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (liver)
GTEx:Tissue enhanced (liver)

Protein evidence

Evidence at protein level

Protein localization

Distinct extra cellular positivity in selected tissues, for examples placenta. Cytoplasmic expression in liver.

ANTIBODY RELIABILITY

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Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding observed and disregarded.

Data reliability

Uncertain based on 4 antibodies.
HPA010607 , HPA023600 , CAB024283 , CAB025339
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (liver)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (liver)

Organ

Expression



GENE INFORMATION

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Gene name

AFP (HGNC Symbol)

Synonyms

FETA, HPAFP

Description

Alpha-fetoprotein (HGNC Symbol)

Entrez gene summary

This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

q13.3

Chromosome location (bp)

73431138 - 73456174

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000081051 (version 78.38)

Entrez gene

174

UniProt

P02771 (UniProt - Evidence at protein level)

neXtProt

NX_P02771

Antibodypedia

AFP antibodies


PROTEIN BROWSER

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ENST00000226359
 
ENST00000395792
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AFP-001 ENSP00000379138
ENST00000395792
P02771
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Show » Show » 609 68.7 Yes 0
AFP-003 ENSP00000226359
ENST00000226359
J3KMX3
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Show » Show » 622 70.4 Yes 0