AFP

GENE INFORMATION

? »

Gene name

AFP (HGNC Symbol)

Synonyms

FETA, HPAFP

Description

alpha-fetoprotein (HGNC Symbol)

Entrez gene summary

This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008]

Chromosome

4 (Chromosome progress)

Cytoband

q13.3

Chromosome location (bp)

74296855 - 74321891

Ensembl

ENSG00000081051 (version 73.37)

Entrez gene

174

UniProt

P02771 (UniProt - Evidence at protein level)

neXtProt

NX_P02771

Antibodypedia

AFP antibodies
 

PROTEIN VIEW

? »
 
 
 
AFP-001
 
AFP-003
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AFP-001 ENSP00000379138
ENST00000395792
P02771
Show all »
Show » Show » 609 68.7 Yes 0
AFP-003 ENSP00000226359
ENST00000226359
J3KMX3
Show all »
Show » Show » 622 70.4 Yes 0