ARG2

GENERAL INFORMATION

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Gene name

ARG2

Gene description

Arginase 2

Protein class

Cancer-related genes
Enzymes
Mitochondrial proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (kidney, prostate, thyroid gland)
GTEx:Tissue enhanced (prostate)

Protein evidence

Evidence at protein level

Protein localization

Granular cytoplasmic expression in selected tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 2 antibodies.
HPA000663 , CAB009435
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Prostate



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (kidney, prostate, thyroid gland)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (prostate)

Organ

Expression



GENE INFORMATION

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Gene name

ARG2

Synonyms

Description

Arginase 2 (HGNC Symbol)

Entrez gene summary

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008]

Chromosome

14

Cytoband

q24.1

Chromosome location (bp)

67619798 - 67651720

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000081181 (version 78.38)

Entrez gene

384

UniProt

P78540 (UniProt - Evidence at protein level)

neXtProt

NX_P78540

Antibodypedia

ARG2 antibodies


PROTEIN BROWSER

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ENST00000261783
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ARG2-001 ENSP00000261783
ENST00000261783
P78540
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