PHLPP1

GENE INFORMATION

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Gene name

PHLPP1 (HGNC Symbol)

Synonyms

KIAA0606, PHLPP, PLEKHE1, SCOP

Description

PH domain and leucine rich repeat protein phosphatase 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011]

Chromosome

18 (Chromosome progress)

Cytoband

q21.33

Chromosome location (bp)

60382672 - 60647666

Ensembl

ENSG00000081913 (version 73.37)

Entrez gene

23239

UniProt

O60346 (UniProt - Evidence at protein level)

neXtProt

NX_O60346

Antibodypedia

PHLPP1 antibodies
 

PROTEIN VIEW

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PHLPP1-001
 
PHLPP1-004
 
PHLPP1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PHLPP1-001 ENSP00000262719
ENST00000262719
O60346
Show all »
Show » Show » 1717 184.7 No 0
PHLPP1-004 ENSP00000467279
ENST00000591386
Show » 198 22.5 No 0
PHLPP1-201 ENSP00000383170
ENST00000400316
O60346
Show all »
Show » Show » 1205 133.6 No 0