STRADB

GENE INFORMATION

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Gene name

STRADB (HGNC Symbol)

Synonyms

ALS2CR2, CALS-21, ILPIP, ILPIPA, PAPK

Description

STE20-related kinase adaptor beta (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Chromosome

2 (Chromosome progress)

Cytoband

q33.1

Chromosome location (bp)

202252581 - 202345569

Ensembl

ENSG00000082146 (version 73.37)

Entrez gene

55437

UniProt

Q9C0K7 (UniProt - Evidence at protein level)

neXtProt

NX_Q9C0K7

Antibodypedia

STRADB antibodies
 

PROTEIN VIEW

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STRADB-001
 
STRADB-003
 
STRADB-005
 
STRADB-006
 
STRADB-009
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

STRADB-001 ENSP00000194530
ENST00000194530
Q9C0K7
Show all »
Show » Show » 418 47 No 0
STRADB-003 ENSP00000376080
ENST00000392249
Q9C0K7
Show all »
Show » Show » 377 42.4 No 0
STRADB-005 ENSP00000404359
ENST00000447698
F8WCQ7
Show all »
37 4.3 No 0
STRADB-006 ENSP00000409552
ENST00000458269
C9JSU7
Show all »
Show » Show » 194 22 No 0
STRADB-009 ENSP00000413574
ENST00000415688
Show » 89 10.1 No 0