ME2

GENE INFORMATION

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Gene name

ME2

Synonyms

Description

malic enzyme 2, NAD(+)-dependent, mitochondrial (HGNC Symbol)

Entrez gene summary

This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq, Dec 2009]

Chromosome

18 (Chromosome progress)

Cytoband

q21.2

Chromosome location (bp)

48405419 - 48474691

Ensembl

ENSG00000082212 (version 73.37)

Entrez gene

4200

UniProt

P23368 (UniProt - Evidence at protein level)

neXtProt

NX_P23368

Antibodypedia

ME2 antibodies
 

PROTEIN VIEW

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ME2-001
 
ME2-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ME2-001 ENSP00000321070
ENST00000321341
P23368
Show all »
Show » Show » 584 65.4 No 0
ME2-002 ENSP00000372384
ENST00000382927
P23368
Show all »
Show » Show » 479 53.6 No 0