MRPL22

GENE INFORMATION

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Gene name

MRPL22 (HGNC Symbol)

Synonyms

HSPC158, MRP-L25, RPML25

Description

mitochondrial ribosomal protein L22 (HGNC Symbol)

Entrez gene summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L22 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 4q. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

5 (Chromosome progress)

Cytoband

q33.2

Chromosome location (bp)

154320630 - 154348971

Ensembl

ENSG00000082515 (version 73.37)

Entrez gene

29093

UniProt

Q9NWU5 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NWU5

Antibodypedia

MRPL22 antibodies
 

PROTEIN VIEW

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MRPL22-001
 
MRPL22-002
 
MRPL22-003
 
MRPL22-005
 
MRPL22-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MRPL22-001 ENSP00000431040
ENST00000523037
Q9NWU5
Show all »
Show » Show » 206 23.6 No 0
MRPL22-002 ENSP00000265229
ENST00000265229
Q9NWU5
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Show » Show » 126 14.5 No 0
MRPL22-003 ENSP00000429039
ENST00000522038
E7ESL0
Show all »
Show » 212 24.3 Yes 0
MRPL22-005 ENSP00000411177
ENST00000439747
J3KQY1
Show all »
Show » Show » 232 26.5 No 0
MRPL22-006 ENSP00000430648
ENST00000519059
H0YBZ7
Show all »
38 4.1 No 0