The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right). The lenght of the bar represents the number of patient samples analysed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the immunohistochemistry validation score for that antibody.
The majority of malignant cells showed moderate cytoplasmic and sometimes membranous staining, although most malignancies displayed occasional strongly stained cases e.g. colorectal, testicular, urothelial and skin cancers.
A majority of malignant cells displayed moderate to strong cytoplasmic and membranous immunoreactivity. Strongest staining was observed in breast and urothelial cancers. Several malignant lymphomas, melanomas and renal cancers were negative.
Most of the malignant cells exhibited weak to moderate cytoplasmic positivity. Occasional cases of testicular cancers showed strong cytoplasmic immunoreactivity. Some cases of gliomas, lymphomas and lung cancers were negative.
Validation
Two (or more) antibodies yielding partly similar staining patterns which are consistent with gene/protein characterization data
Two (or more) antibodies yielding partly similar staining patterns which are consistent with gene/protein characterization data
Two (or more) antibodies yielding partly similar staining patterns which are consistent with gene/protein characterization data
