FAT1

GENE INFORMATION

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Gene name

FAT1 (HGNC Symbol)

Synonyms

CDHF7, CDHR8, FAT

Description

FAT atypical cadherin 1 (HGNC Symbol)

Entrez gene summary

This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008]

Chromosome

4 (Chromosome progress)

Cytoband

q35.2

Chromosome location (bp)

187508937 - 187647876

Ensembl

ENSG00000083857 (version 73.37)

Entrez gene

2195

UniProt

Q14517 (UniProt - Evidence at protein level)

neXtProt

NX_Q14517

Antibodypedia

FAT1 antibodies
 

PROTEIN VIEW

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FAT1-001
 
FAT1-002
 
FAT1-003
 
FAT1-005
 
FAT1-010
 
FAT1-011
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FAT1-001 ENSP00000406229
ENST00000441802
Q14517
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Show » Show » 4588 506.3 Yes 1
FAT1-002 ENSP00000423736
ENST00000509647
D6RCE4
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Show » 488 53.9 Yes 0
FAT1-003 ENSP00000420869
ENST00000509927
H0Y8F5
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119 13.2 No 0
FAT1-005 ENSP00000424157
ENST00000512772
368 40.7 No 0
FAT1-010 ENSP00000423801
ENST00000507105
285 31.3 No 0
FAT1-011 ENSP00000421003
ENST00000509537
D6RHE6
Show all »
Show » 52 6 No 0