Metabolic pathway information for HADHA

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HADHA
Gene descriptionⁱ Full gene name according to HGNC.	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry. Read more
RNA tissue specificityⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more	Tissue enhanced (skeletal muscle)
RNA tissue distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

METABOLIC SUMMARYⁱ For selected proteins extended tissue profiling is performed in addition to standard tissue microarrays. The section below contains results from the extended profiling.
Gene HADHA is associated with 272 reactions in 23 different subsystems, and present in the compartments: Cytosol, Mitochondria, Peroxisome. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Beta oxidation of even-chain fatty acids (mitochondrial)	Mitochondria	13	68	50
Beta oxidation of unsaturated fatty acids (n-9) (mitochondrial)	Mitochondria	14	30	15
Fatty acid oxidation	Cytosol, Endoplasmic reticulum, Peroxisome, Mitochondria, Extracellular	69	375	41
Valine, leucine, and isoleucine metabolism	Mitochondria, Cytosol, Peroxisome	74	71	3
Beta oxidation of poly-unsaturated fatty acids (mitochondrial)	Mitochondria	11	34	14
Beta oxidation of odd-chain fatty acids (mitochondrial)	Mitochondria	12	47	27
Beta oxidation of phytanic acid (peroxisomal)	Peroxisome, Cytosol	24	37	3
Beta oxidation of unsaturated fatty acids (n-9) (peroxisomal)	Peroxisome	9	47	11
Beta oxidation of di-unsaturated fatty acids (n-6) (peroxisomal)	Peroxisome	11	28	6
Leukotriene metabolism	Peroxisome, Mitochondria, Cytosol, Endoplasmic reticulum, Nucleus, Extracellular	206	105	19
Vitamin E metabolism	Mitochondria, Cytosol, Endoplasmic reticulum	55	68	13
Beta oxidation of even-chain fatty acids (peroxisomal)	Peroxisome	9	59	12
Beta oxidation of branched-chain fatty acids (mitochondrial)	Mitochondria	10	23	9
Omega-3 fatty acid metabolism	Cytosol, Peroxisome, Nucleus, Endoplasmic reticulum	53	73	1
Beta oxidation of unsaturated fatty acids (n-7) (mitochondrial)	Mitochondria	14	26	12
Arachidonic acid metabolism	Cytosol, Peroxisome, Endoplasmic reticulum, Extracellular, Nucleus, Mitochondria	108	87	6
Beta oxidation of di-unsaturated fatty acids (n-6) (mitochondrial)	Mitochondria	16	28	12
Beta oxidation of unsaturated fatty acids (n-7) (peroxisomal)	Peroxisome	9	17	2
Omega-6 fatty acid metabolism	Cytosol, Mitochondria, Peroxisome	39	56	11
Tryptophan metabolism	Mitochondria, Cytosol	24	40	2
Beta-alanine metabolism	Cytosol, Mitochondria, Peroxisome	21	32	1
Drug metabolism	Cytosol, Mitochondria, Peroxisome, Extracellular, Endoplasmic reticulum	55	210	1
Steroid metabolism	Mitochondria, Cytosol, Endoplasmic reticulum, Golgi apparatus, Lysosome	95	97	1