CAD

GENE INFORMATION

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Gene name

CAD

Synonyms

Description

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (HGNC Symbol)

Entrez gene summary

The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. [provided by RefSeq, Jul 2008]

Chromosome

2 (Chromosome progress)

Cytoband

p23.3

Chromosome location (bp)

27440258 - 27466811

Ensembl

ENSG00000084774 (version 73.37)

Entrez gene

790

UniProt

P27708 (UniProt - Evidence at protein level)

neXtProt

NX_P27708

Antibodypedia

CAD antibodies
 

PROTEIN VIEW

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CAD-001
 
CAD-002
 
CAD-004
 
CAD-008
 
CAD-011
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CAD-001 ENSP00000264705
ENST00000264705
P27708
Show all »
Show » Show » 2225 243 No 0
CAD-002 ENSP00000384510
ENST00000403525
F8VPD4
Show all »
Show » Show » 2162 236 No 0
CAD-004 ENSP00000388740
ENST00000456311
Show » 280 31.1 No 0
CAD-008 ENSP00000414742
ENST00000458503
Show » 269 28.9 No 0
CAD-011 ENSP00000405416
ENST00000428460
Show » Show » 293 32.2 No 0