CD59

GENE INFORMATION

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Gene name

CD59 (HGNC Symbol)

Synonyms

16.3A5, EJ16, EJ30, EL32, G344, MIC11, MIN1, MIN2, MIN3, MSK21, p18-20

Description

CD59 molecule, complement regulatory protein (HGNC Symbol)

Entrez gene summary

This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

11 (Chromosome progress)

Cytoband

p13

Chromosome location (bp)

33719807 - 33757991

Ensembl

ENSG00000085063 (version 73.37)

Entrez gene

966

UniProt

P13987 (UniProt - Evidence at protein level)

neXtProt

NX_P13987

Antibodypedia

CD59 antibodies
 

PROTEIN VIEW

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CD59-001
 
CD59-002
 
CD59-003
 
CD59-005
 
CD59-006
 
CD59-007
 
CD59-008
 
CD59-009
 
CD59-010
 
CD59-011
 
CD59-012
 
CD59-013
 
CD59-014
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CD59-001 ENSP00000340210
ENST00000351554
P13987
Show all »
Show » Show » 128 14.2 Yes 1
CD59-002 ENSP00000379191
ENST00000395850
P13987
Show all »
Show » Show » 128 14.2 Yes 1
CD59-003 ENSP00000404822
ENST00000415002
P13987
Show all »
Show » Show » 128 14.2 Yes 1
CD59-005 ENSP00000432942
ENST00000527577
P13987
Show all »
Show » Show » 128 14.2 Yes 1
CD59-006 ENSP00000434617
ENST00000528700
P13987
Show all »
Show » Show » 128 14.2 Yes 1
CD59-007 ENSP00000402425
ENST00000426650
P13987
Show all »
Show » Show » 128 14.2 Yes 1
CD59-008 ENSP00000403511
ENST00000445143
P13987
Show all »
Show » Show » 128 14.2 Yes 1
CD59-009 ENSP00000410182
ENST00000437761
P13987
Show all »
Show » Show » 128 14.2 Yes 1
CD59-010 ENSP00000436737
ENST00000533403
E9PI80
Show all »
Show » Show » 119 13 Yes 0
CD59-011 ENSP00000435179
ENST00000525763
P13987
Show all »
Show » Show » 128 14.2 Yes 1
CD59-012 ENSP00000432362
ENST00000534312
E9PR17
Show all »
Show » Show » 130 14.5 Yes 0
CD59-013 ENSP00000437122
ENST00000527926
E9PNW4
Show all »
Show » Show » 108 12 Yes 0
CD59-014 ENSP00000436497
ENST00000533181
Show » 52 5.8 No 0