MAP3K4

GENE INFORMATION

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Gene name

MAP3K4 (HGNC Symbol)

Synonyms

KIAA0213, MAPKKK4, MEKK4, MTK1

Description

Mitogen-activated protein kinase kinase kinase 4 (HGNC Symbol)

Entrez gene summary

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

q26

Chromosome location (bp)

161412759 - 161538417

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000085511 (version 75.37)

Entrez gene

4216

UniProt

Q9Y6R4 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y6R4

Antibodypedia

MAP3K4 antibodies
 

PROTEIN VIEW

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MAP3K4-001
 
MAP3K4-002
 
MAP3K4-004
 
MAP3K4-005
 
MAP3K4-006
 
MAP3K4-007
 
MAP3K4-009
 
MAP3K4-010
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAP3K4-001 ENSP00000375986
ENST00000392142
Q9Y6R4
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Show » Show » 1608 181.7 No 0
MAP3K4-002 ENSP00000355886
ENST00000366919
Q9Y6R4
Show all »
Show » Show » 1558 177 No 0
MAP3K4-004 ENSP00000446303
ENST00000490904
F5H1X6
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Show » Show » 636 71.7 No 0
MAP3K4-005 ENSP00000445018
ENST00000544041
F5H4R1
Show all »
Show » Show » 1442 163 No 0
MAP3K4-006 ENSP00000355887
ENST00000366920
F5H538
Show all »
Show » Show » 1604 181.2 No 0
MAP3K4-007 ENSP00000297332
ENST00000348824
J3KNB8
Show all »
Show » Show » 1554 176.6 No 0
MAP3K4-009 ENSP00000439377
ENST00000542952
F5H2S6
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Show » 85 9 No 0
MAP3K4-010 ENSP00000390508
ENST00000448119
F5H534
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Show » Show » 23 2.7 No 0