ABCB1

GENE INFORMATION

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Gene name

ABCB1 (HGNC Symbol)

Synonyms

ABC20, CD243, CLCS, GP170, MDR1, P-gp, PGY1

Description

ATP-binding cassette, sub-family B (MDR/TAP), member 1 (HGNC Symbol)

Entrez gene summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]

Chromosome

7 (Chromosome progress)

Cytoband

q21.12

Chromosome location (bp)

87133175 - 87342611

Ensembl

ENSG00000085563 (version 73.37)

Entrez gene

5243

UniProt

P08183 (UniProt - Evidence at protein level)

neXtProt

NX_P08183

Antibodypedia

ABCB1 antibodies
 

PROTEIN VIEW

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ABCB1-001
 
ABCB1-003
 
ABCB1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABCB1-001 ENSP00000265724
ENST00000265724
P08183
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Show » Show » 1280 141.5 No >9
ABCB1-003 ENSP00000399419
ENST00000416177
E7EWT8
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48 5.7 No 0
ABCB1-201 ENSP00000444095
ENST00000543898
B5AK60
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Show » Show » 1216 134 No >9