The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right). The lenght of the bar represents the number of patient samples analysed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the immunohistochemistry validation score for that antibody.
Renal cancers exhibited moderate to strong cytoplasmic staining while a majority of testicular cancers, thyroid cancers, malignant gliomas and lymphomas displayed moderate immunoreactivity. The remaining tumors generally showed weak staining or were negative.
Malignant gliomas, testicular seminomas and a few renal cancers showed weak to moderate cytoplasmic and nuclear immunoreactivity. Malignant cells in general were negative.
Many renal and thyroid cancers showed moderate to strong staining in cytoplasm and nucleus while a majority of ovarian cancers, urothelial cancers, malignant gliomas, lymphomas and melanomas showed weak to moderate staining. Remaining malignancies were generally negative.
Validation
Two (or more) antibodies yielding partly similar staining patterns which are consistent with gene/protein characterization data
Two (or more) antibodies yielding partly similar staining patterns which are consistent with gene/protein characterization data
Two (or more) antibodies yielding partly similar staining patterns which are consistent with gene/protein characterization data
