AKR1B1

GENE INFORMATION

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Gene name

AKR1B1 (HGNC Symbol)

Synonyms

ALDR1, AR

Description

aldo-keto reductase family 1, member B1 (aldose reductase) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]

Chromosome

7 (Chromosome progress)

Cytoband

q33

Chromosome location (bp)

134127102 - 134144036

Ensembl

ENSG00000085662 (version 73.37)

Entrez gene

231

UniProt

P15121 (UniProt - Evidence at protein level)

neXtProt

NX_P15121

Antibodypedia

AKR1B1 antibodies
 

PROTEIN VIEW

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AKR1B1-001
 
AKR1B1-002
 
AKR1B1-009
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AKR1B1-001 ENSP00000285930
ENST00000285930
P15121
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Show » Show » 316 35.9 No 0
AKR1B1-002 ENSP00000414399
ENST00000434222
E9PCX2
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Show » 263 29.4 No 0
AKR1B1-009 ENSP00000413205
ENST00000426422
E9PEF9
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Show » 102 11 No 0