CTTN

GENE INFORMATION

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Gene name

CTTN (HGNC Symbol)

Synonyms

EMS1

Description

cortactin (HGNC Symbol)

Entrez gene summary

This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]

Chromosome

11 (Chromosome progress)

Cytoband

q13.3

Chromosome location (bp)

70244510 - 70282690

Ensembl

ENSG00000085733 (version 73.37)

Entrez gene

2017

UniProt

Q14247 (UniProt - Evidence at protein level)

neXtProt

NX_Q14247

Antibodypedia

CTTN antibodies
 

PROTEIN VIEW

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CTTN-001
 
CTTN-002
 
CTTN-005
 
CTTN-007
 
CTTN-008
 
CTTN-009
 
CTTN-012
 
CTTN-014
 
CTTN-016
 
CTTN-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CTTN-001 ENSP00000317189
ENST00000346329
Q14247
Show all »
Show » Show » 513 57.5 No 0
CTTN-002 ENSP00000301843
ENST00000301843
Q14247
Show all »
Show » Show » 550 61.6 No 0
CTTN-005 ENSP00000409014
ENST00000415461
223 25 No 0
CTTN-007 ENSP00000434669
ENST00000498223
E9PP90
Show all »
Show » 76 8.8 No 0
CTTN-008 ENSP00000365745
ENST00000376561
Q14247
Show all »
Show » Show » 634 71 No 0
CTTN-009 ENSP00000377348
ENST00000393747
H7BYK6
Show all »
72 8.3 Yes 0
CTTN-012 ENSP00000433552
ENST00000527962
E9PKG3
Show all »
Show » 51 5.8 No 0
CTTN-014 ENSP00000436613
ENST00000533931
H0YEV2
Show all »
Show » 128 14.3 No 0
CTTN-016 ENSP00000431421
ENST00000529736
H0YCD9
Show all »
Show » Show » 265 29.6 No 0
CTTN-201 ENSP00000439762
ENST00000538675
B4E358
Show all »
Show » Show » 314 35.3 No 0