MTIF2

GENE INFORMATION

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Gene name

MTIF2 (HGNC Symbol)

Synonyms

IF-2mt

Description

mitochondrial translational initiation factor 2 (HGNC Symbol)

Entrez gene summary

During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

2 (Chromosome progress)

Cytoband

p16.1

Chromosome location (bp)

55463731 - 55496483

Ensembl

ENSG00000085760 (version 73.37)

Entrez gene

4528

UniProt

P46199 (UniProt - Evidence at protein level)

neXtProt

NX_P46199

Antibodypedia

MTIF2 antibodies
 

PROTEIN VIEW

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MTIF2-001
 
MTIF2-002
 
MTIF2-005
 
MTIF2-007
 
MTIF2-008
 
MTIF2-009
 
MTIF2-010
 
MTIF2-011
 
MTIF2-012
 
MTIF2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MTIF2-001 ENSP00000263629
ENST00000263629
P46199
Show all »
Show » 727 81.3 No 0
MTIF2-002 ENSP00000384481
ENST00000403721
P46199
Show all »
Show » 727 81.3 No 0
MTIF2-005 ENSP00000393337
ENST00000366137
E7EW07
Show all »
Show » 72 8.6 No 0
MTIF2-007 ENSP00000388640
ENST00000441307
E7ESE3
Show all »
Show » 71 8.5 No 0
MTIF2-008 ENSP00000416057
ENST00000420637
C9JIY5
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Show » 26 3.2 No 0
MTIF2-009 ENSP00000383880
ENST00000404297
B5MCU1
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Show » 70 8.4 No 0
MTIF2-010 ENSP00000403492
ENST00000418823
Show » 301 33.5 No 0
MTIF2-011 ENSP00000393025
ENST00000412530
7 0.9 No 0
MTIF2-012 ENSP00000399531
ENST00000417363
10 1.2 No 0
MTIF2-201 ENSP00000378099
ENST00000394600
P46199
Show all »
Show » 727 81.3 No 0