The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right). The lenght of the bar represents the number of patient samples analysed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the immunohistochemistry validation score for that antibody.
A majority of malignant cells showed moderate to strong staining. Most malignant gliomas and lymphomas as well as several prostate, lung, ovarian and testicular cancers were weakly stained or negative.
Malignant cells generally showed weak staining or were negative. Basal cell carcinomas showed moderate to strong staining.
Malignant cells generally showed weak to moderate cytoplasmic immunoreactivity.
Thyroid cancers and several squamous cell carcinomas in skin exhibited strong cytoplasmic immunoreactivity. Moderate cytoplasmic and membranous positivity was observed in cases of cholangiocarcinomas, ovarian, cervical, endometrial, lung and pancreatic cancers. Malignant cells in general were negative.
Validation
Two (or more) antibodies yielding partly similar staining patterns which are consistent with gene/protein characterization data
Two (or more) antibodies yielding partly similar staining patterns which are consistent with gene/protein characterization data
Two (or more) antibodies yielding partly similar staining patterns which are consistent with gene/protein characterization data
Two (or more) antibodies yielding partly similar staining patterns which are partly consistent with gene/protein characterization data or consistent with limited gene/protein characterization data
