FOLH1

GENE INFORMATION

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Gene name

FOLH1 (HGNC Symbol)

Synonyms

FOLH, GCP2, GCPII, NAALAD1, NAALAdase, PSM, PSMA

Description

folate hydrolase (prostate-specific membrane antigen) 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]

Chromosome

11 (Chromosome progress)

Cytoband

p11.12

Chromosome location (bp)

49168187 - 49230222

Ensembl

ENSG00000086205 (version 73.37)

Entrez gene

2346

UniProt

Q04609 (UniProt - Evidence at protein level)

neXtProt

NX_Q04609

Antibodypedia

FOLH1 antibodies
 

PROTEIN VIEW

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FOLH1-001
 
FOLH1-002
 
FOLH1-003
 
FOLH1-004
 
FOLH1-005
 
FOLH1-010
 
FOLH1-012
 
FOLH1-013
 
FOLH1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FOLH1-001 ENSP00000256999
ENST00000256999
Q04609
Show all »
Show » Show » 750 84.3 No 1
FOLH1-002 ENSP00000349129
ENST00000356696
Q04609
Show all »
Show » Show » 719 80.6 No 1
FOLH1-003 ENSP00000344131
ENST00000340334
Q04609
Show all »
Show » Show » 735 82.5 No 0
FOLH1-004 ENSP00000431463
ENST00000533034
Q04609
Show all »
Show » Show » 704 78.8 No 0
FOLH1-005 ENSP00000434928
ENST00000525826
E9PMK6
Show all »
Show » Show » 74 8.4 No 1
FOLH1-010 ENSP00000431263
ENST00000529648
E9PLV0
Show all »
Show » 48 5.2 No 1
FOLH1-012 ENSP00000436569
ENST00000533510
E9PI29
Show all »
Show » 46 5.1 No 1
FOLH1-013 ENSP00000431577
ENST00000529117
E9PKM3
Show all »
Show » 64 7.5 No 0
FOLH1-201 ENSP00000344086
ENST00000343844
Q04609
Show all »
Show » Show » 442 50.1 No 0