HUWE1

GENE INFORMATION

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Gene name

HUWE1 (HGNC Symbol)

Synonyms

Ib772, KIAA0312, UREB1

Description

HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic mental retardation. [provided by RefSeq, Aug 2013]

Chromosome

X (Chromosome progress)

Cytoband

p11.22

Chromosome location (bp)

53559057 - 53713673

Ensembl

ENSG00000086758 (version 73.37)

Entrez gene

10075

UniProt

Q7Z6Z7 (UniProt - Evidence at protein level)

neXtProt

NX_Q7Z6Z7

Antibodypedia

HUWE1 antibodies
 

PROTEIN VIEW

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HUWE1-001
 
HUWE1-002
 
HUWE1-005
 
HUWE1-007
 
HUWE1-009
 
HUWE1-010
 
HUWE1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HUWE1-001 ENSP00000340648
ENST00000342160
Q7Z6Z7
Show all »
Show » Show » 4374 481.9 No 1
HUWE1-002 ENSP00000401253
ENST00000427052
Q5H924
Show all »
Show » Show » 3408 374.2 No 0
HUWE1-005 ENSP00000403236
ENST00000426907
Q5H935
Show all »
Show » Show » 1197 133.2 No 0
HUWE1-007 ENSP00000218328
ENST00000218328
Q5H962
Show all »
Show » Show » 1672 186.2 No 0
HUWE1-009 ENSP00000415122
ENST00000424562
Q5H964
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228 23.8 No 0
HUWE1-010 ENSP00000413651
ENST00000446750
Q5H963
Show all »
93 10.9 No 0
HUWE1-201 ENSP00000262854
ENST00000262854
Q7Z6Z7
Show all »
Show » Show » 4374 481.9 No 1