NOX4

GENE INFORMATION

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Gene name

NOX4 (HGNC Symbol)

Synonyms

KOX, KOX-1

Description

NADPH oxidase 4 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]

Chromosome

11 (Chromosome progress)

Cytoband

q14.3

Chromosome location (bp)

89057524 - 89322779

Ensembl

ENSG00000086991 (version 73.37)

Entrez gene

50507

UniProt

Q9NPH5 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NPH5

Antibodypedia

NOX4 antibodies
 

PROTEIN VIEW

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 « 
 
NOX4-001
 
NOX4-002
 
NOX4-003
 
NOX4-004
 
NOX4-005
 
NOX4-006
 
NOX4-007
 
NOX4-008
 
NOX4-009
 
NOX4-010
 
NOX4-012
 
NOX4-013
 
NOX4-201
 
NOX4-202
 
NOX4-203
 
NOX4-204
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NOX4-001 ENSP00000263317
ENST00000263317
Q9NPH5
Show all »
Show » Show » 578 66.9 No 7
NOX4-002 ENSP00000433797
ENST00000527956
E7EMD7
Show all »
Show » Show » 554 64.1 No 6
NOX4-003 ENSP00000376961
ENST00000393282
Q9NPH5
Show all »
Show » Show » 54 6.5 No 1
NOX4-004 ENSP00000434924
ENST00000532825
E9PMY6
Show all »
Show » Show » 514 59.9 No 5
NOX4-005 ENSP00000344747
ENST00000343727
E7EMD7
Show all »
Show » Show » 554 64.1 No 6
NOX4-006 ENSP00000436970
ENST00000528341
E9PPP2
Show all »
Show » Show » 553 63.5 No 6
NOX4-007 ENSP00000436093
ENST00000527626
E9PR43
Show all »
Show » Show » 391 45.5 Yes 3
NOX4-008 ENSP00000436716
ENST00000525196
E9PI95
Show all »
Show » Show » 342 40.1 No 5
NOX4-009 ENSP00000365146
ENST00000375979
Q9NPH5
Show all »
Show » Show » 271 31.8 No 2
NOX4-010 ENSP00000435039
ENST00000531342
Q9NPH5
Show all »
Show » Show » 231 27.6 No 1
NOX4-012 ENSP00000435474
ENST00000529343
Q9NPH5
Show all »
Show » Show » 224 25.8 No 5
NOX4-013 ENSP00000436892
ENST00000534731
Q9NPH5
Show all »
Show » Show » 538 62.7 No 6
NOX4-201 ENSP00000405705
ENST00000413594
C9J897
Show all »
Show » Show » 599 69.7 No 7
NOX4-202 ENSP00000412446
ENST00000424319
E7EMD7
Show all »
Show » Show » 554 64.1 No 6
NOX4-203 ENSP00000440172
ENST00000535633
E7EMD7
Show all »
Show » Show » 554 64.1 No 6
NOX4-204 ENSP00000439373
ENST00000542487
E7EMD7
Show all »
Show » Show » 554 64.1 No 6