The Human Protein Atlas

GENE INFORMATION

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Gene name	ACHE (HGNC Symbol)
Synonyms	YT
Description	acetylcholinesterase (HGNC Symbol)
Entrez gene summary	Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq, Jul 2008]
Chromosome	7 (Chromosome progress)
Cytoband	q22.1
Chromosome location (bp)	100487615 - 100494594
Ensembl	ENSG00000087085 (version 69.37)
Entrez gene	43
UniProt	P22303
neXtProt	NX_P22303
Antibodypedia	ACHE antibodies

PROTEIN VIEW

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ACHE-001		ACHE-002		ACHE-003		ACHE-004		ACHE-006		ACHE-007		ACHE-008		ACHE-009		ACHE-010		ACHE-011		ACHE-012		ACHE-013		ACHE-201

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
ACHE-001	ENSP00000241069 ENST00000241069	P22303 Show all » « Hide P22303 [Direct mapping] Acetylcholinesterase C9JD78 [Target identity:25%; Query identity:100%] Acetylcholinesterase C9JUK5 [Target identity:4%; Query identity:100%] Acetylcholinesterase	Show » « Hide Blood group antigen proteins Enzymes Hydrolases Potential transmembrane proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0001507 [acetylcholine catabolic process in synaptic cleft] GO:0001540 [beta-amyloid binding] GO:0001919 [regulation of receptor recycling] GO:0002076 [osteoblast development] GO:0003990 [acetylcholinesterase activity] GO:0004091 [carboxylesterase activity] GO:0004104 [cholinesterase activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005576 [extracellular region] GO:0005605 [basal lamina] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006260 [DNA replication] GO:0006581 [acetylcholine catabolic process] GO:0007155 [cell adhesion] GO:0007268 [synaptic transmission] GO:0007271 [synaptic transmission, cholinergic] GO:0007399 [nervous system development] GO:0007416 [synapse assembly] GO:0007517 [muscle organ development] GO:0008283 [cell proliferation] GO:0009611 [response to wounding] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016787 [hydrolase activity] GO:0017171 [serine hydrolase activity] GO:0019695 [choline metabolic process] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030425 [dendrite] GO:0031225 [anchored to membrane] GO:0031594 [neuromuscular junction] GO:0031623 [receptor internalization] GO:0032223 [negative regulation of synaptic transmission, cholinergic] GO:0042136 [neurotransmitter biosynthetic process] GO:0042166 [acetylcholine binding] GO:0042734 [presynaptic membrane] GO:0042803 [protein homodimerization activity] GO:0042982 [amyloid precursor protein metabolic process] GO:0043083 [synaptic cleft] GO:0043236 [laminin binding] GO:0043621 [protein self-association] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0045212 [neurotransmitter receptor biosynthetic process] GO:0048471 [perinuclear region of cytoplasm] GO:0048814 [regulation of dendrite morphogenesis] GO:0050714 [positive regulation of protein secretion] GO:0050770 [regulation of axonogenesis] GO:0051262 [protein tetramerization] GO:0060041 [retina development in camera-type eye]	614	67.8	Yes	0
ACHE-002	ENSP00000403474 ENST00000419336	P22303 Show all » « Hide P22303 [Direct mapping] Acetylcholinesterase C9JD78 [Target identity:30%; Query identity:100%] Acetylcholinesterase C9JUK5 [Target identity:5%; Query identity:100%] Acetylcholinesterase	Show » « Hide Blood group antigen proteins Enzymes Hydrolases Potential transmembrane proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0001507 [acetylcholine catabolic process in synaptic cleft] GO:0001540 [beta-amyloid binding] GO:0001919 [regulation of receptor recycling] GO:0002076 [osteoblast development] GO:0003990 [acetylcholinesterase activity] GO:0004091 [carboxylesterase activity] GO:0004104 [cholinesterase activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005576 [extracellular region] GO:0005605 [basal lamina] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006260 [DNA replication] GO:0006581 [acetylcholine catabolic process] GO:0007155 [cell adhesion] GO:0007268 [synaptic transmission] GO:0007271 [synaptic transmission, cholinergic] GO:0007399 [nervous system development] GO:0007416 [synapse assembly] GO:0007517 [muscle organ development] GO:0008283 [cell proliferation] GO:0009611 [response to wounding] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016787 [hydrolase activity] GO:0017171 [serine hydrolase activity] GO:0019695 [choline metabolic process] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030425 [dendrite] GO:0031225 [anchored to membrane] GO:0031594 [neuromuscular junction] GO:0031623 [receptor internalization] GO:0032223 [negative regulation of synaptic transmission, cholinergic] GO:0042136 [neurotransmitter biosynthetic process] GO:0042166 [acetylcholine binding] GO:0042734 [presynaptic membrane] GO:0042803 [protein homodimerization activity] GO:0042982 [amyloid precursor protein metabolic process] GO:0043083 [synaptic cleft] GO:0043236 [laminin binding] GO:0043621 [protein self-association] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0045212 [neurotransmitter receptor biosynthetic process] GO:0048471 [perinuclear region of cytoplasm] GO:0048814 [regulation of dendrite morphogenesis] GO:0050714 [positive regulation of protein secretion] GO:0050770 [regulation of axonogenesis] GO:0051262 [protein tetramerization] GO:0060041 [retina development in camera-type eye]	526	58.4	Yes	0
ACHE-003	ENSP00000404865 ENST00000411582	P22303 Show all » « Hide P22303 [Direct mapping] Acetylcholinesterase C9JD78 [Target identity:25%; Query identity:100%] Acetylcholinesterase C9JUK5 [Target identity:4%; Query identity:100%] Acetylcholinesterase	Show » « Hide Blood group antigen proteins Enzymes Hydrolases Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins 1TM proteins predicted by MDM Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0001507 [acetylcholine catabolic process in synaptic cleft] GO:0001540 [beta-amyloid binding] GO:0001919 [regulation of receptor recycling] GO:0002076 [osteoblast development] GO:0003990 [acetylcholinesterase activity] GO:0004091 [carboxylesterase activity] GO:0004104 [cholinesterase activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005576 [extracellular region] GO:0005605 [basal lamina] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006260 [DNA replication] GO:0006581 [acetylcholine catabolic process] GO:0007155 [cell adhesion] GO:0007268 [synaptic transmission] GO:0007271 [synaptic transmission, cholinergic] GO:0007399 [nervous system development] GO:0007416 [synapse assembly] GO:0007517 [muscle organ development] GO:0008283 [cell proliferation] GO:0009611 [response to wounding] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016787 [hydrolase activity] GO:0017171 [serine hydrolase activity] GO:0019695 [choline metabolic process] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030425 [dendrite] GO:0031225 [anchored to membrane] GO:0031594 [neuromuscular junction] GO:0031623 [receptor internalization] GO:0032223 [negative regulation of synaptic transmission, cholinergic] GO:0042136 [neurotransmitter biosynthetic process] GO:0042166 [acetylcholine binding] GO:0042734 [presynaptic membrane] GO:0042803 [protein homodimerization activity] GO:0042982 [amyloid precursor protein metabolic process] GO:0043083 [synaptic cleft] GO:0043236 [laminin binding] GO:0043621 [protein self-association] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0045212 [neurotransmitter receptor biosynthetic process] GO:0048471 [perinuclear region of cytoplasm] GO:0048814 [regulation of dendrite morphogenesis] GO:0050714 [positive regulation of protein secretion] GO:0050770 [regulation of axonogenesis] GO:0051262 [protein tetramerization] GO:0060041 [retina development in camera-type eye]	617	67.4	Yes	1
ACHE-004	ENSP00000400933 ENST00000445236	C9JUK5 Show all » « Hide C9JUK5 [Target identity:100%; Query identity:100%] Acetylcholinesterase E7ENT6 [Target identity:100%; Query identity:30%] Acetylcholinesterase Q6TQD3 [Target identity:100%; Query identity:29%] N-terminal extended acetylcholinesterase	Show » « Hide Potential transmembrane proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins TMHMM predicted membrane proteins Potentially secreted proteins SPOCTOPUS predicted secreted proteins	Show » « Hide GO:0001919 [regulation of receptor recycling] GO:0003990 [acetylcholinesterase activity] GO:0005605 [basal lamina] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006581 [acetylcholine catabolic process] GO:0009986 [cell surface] GO:0031594 [neuromuscular junction] GO:0031623 [receptor internalization] GO:0043236 [laminin binding] GO:0043621 [protein self-association] GO:0045212 [neurotransmitter receptor biosynthetic process] GO:0051262 [protein tetramerization] GO:0060041 [retina development in camera-type eye]	28	3	No	0
ACHE-006	ENSP00000414858 ENST00000428317	P22303 Show all » « Hide P22303 [Direct mapping] Acetylcholinesterase C9JD78 [Target identity:25%; Query identity:100%] Acetylcholinesterase C9JUK5 [Target identity:4%; Query identity:100%] Acetylcholinesterase	Show » « Hide Blood group antigen proteins Enzymes Hydrolases Potential transmembrane proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0001507 [acetylcholine catabolic process in synaptic cleft] GO:0001540 [beta-amyloid binding] GO:0001919 [regulation of receptor recycling] GO:0002076 [osteoblast development] GO:0003990 [acetylcholinesterase activity] GO:0004091 [carboxylesterase activity] GO:0004104 [cholinesterase activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005576 [extracellular region] GO:0005605 [basal lamina] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006260 [DNA replication] GO:0006581 [acetylcholine catabolic process] GO:0007155 [cell adhesion] GO:0007268 [synaptic transmission] GO:0007271 [synaptic transmission, cholinergic] GO:0007399 [nervous system development] GO:0007416 [synapse assembly] GO:0007517 [muscle organ development] GO:0008283 [cell proliferation] GO:0009611 [response to wounding] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016787 [hydrolase activity] GO:0017171 [serine hydrolase activity] GO:0019695 [choline metabolic process] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030425 [dendrite] GO:0031225 [anchored to membrane] GO:0031594 [neuromuscular junction] GO:0031623 [receptor internalization] GO:0032223 [negative regulation of synaptic transmission, cholinergic] GO:0042136 [neurotransmitter biosynthetic process] GO:0042166 [acetylcholine binding] GO:0042734 [presynaptic membrane] GO:0042803 [protein homodimerization activity] GO:0042982 [amyloid precursor protein metabolic process] GO:0043083 [synaptic cleft] GO:0043236 [laminin binding] GO:0043621 [protein self-association] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0045212 [neurotransmitter receptor biosynthetic process] GO:0048471 [perinuclear region of cytoplasm] GO:0048814 [regulation of dendrite morphogenesis] GO:0050714 [positive regulation of protein secretion] GO:0050770 [regulation of axonogenesis] GO:0051262 [protein tetramerization] GO:0060041 [retina development in camera-type eye]	614	67.8	Yes	0
ACHE-007	ENSP00000396360 ENST00000441605	C9JD78 Show all » « Hide C9JD78 [Target identity:100%; Query identity:100%] Acetylcholinesterase C9JUK5 [Target identity:17%; Query identity:100%] Acetylcholinesterase	Show » « Hide Potential transmembrane proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins	Show » « Hide GO:0001919 [regulation of receptor recycling] GO:0003990 [acetylcholinesterase activity] GO:0005605 [basal lamina] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006581 [acetylcholine catabolic process] GO:0009986 [cell surface] GO:0031594 [neuromuscular junction] GO:0031623 [receptor internalization] GO:0043236 [laminin binding] GO:0043621 [protein self-association] GO:0045212 [neurotransmitter receptor biosynthetic process] GO:0051262 [protein tetramerization] GO:0060041 [retina development in camera-type eye]	159	17.4	Yes	0
ACHE-008	ENSP00000397143 ENST00000426415	C9J2S3 Show all » « Hide C9J2S3 [Target identity:100%; Query identity:100%] Acetylcholinesterase C9JD78 [Target identity:39%; Query identity:100%] Acetylcholinesterase C9JUK5 [Target identity:7%; Query identity:100%] Acetylcholinesterase	Show » « Hide Potential transmembrane proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins	Show » « Hide GO:0001919 [regulation of receptor recycling] GO:0003990 [acetylcholinesterase activity] GO:0004104 [cholinesterase activity] GO:0005605 [basal lamina] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006581 [acetylcholine catabolic process] GO:0009986 [cell surface] GO:0031594 [neuromuscular junction] GO:0031623 [receptor internalization] GO:0043236 [laminin binding] GO:0043621 [protein self-association] GO:0045212 [neurotransmitter receptor biosynthetic process] GO:0051262 [protein tetramerization] GO:0060041 [retina development in camera-type eye]	398	42.6	Yes	0
ACHE-009	ENSP00000390004 ENST00000454485	F8WD68 Show all » « Hide F8WD68 [Target identity:100%; Query identity:100%] Acetylcholinesterase C9JD78 [Target identity:39%; Query identity:100%] Acetylcholinesterase C9JUK5 [Target identity:6%; Query identity:100%] Acetylcholinesterase	Show » « Hide Potential transmembrane proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins	Show » « Hide GO:0001919 [regulation of receptor recycling] GO:0003990 [acetylcholinesterase activity] GO:0004104 [cholinesterase activity] GO:0005605 [basal lamina] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006581 [acetylcholine catabolic process] GO:0009986 [cell surface] GO:0031594 [neuromuscular junction] GO:0031623 [receptor internalization] GO:0043236 [laminin binding] GO:0043621 [protein self-association] GO:0045212 [neurotransmitter receptor biosynthetic process] GO:0051262 [protein tetramerization] GO:0060041 [retina development in camera-type eye]	403	43.3	Yes	0
ACHE-010	ENSP00000410380 ENST00000440755	F8WAR7 Show all » « Hide F8WAR7 [Target identity:100%; Query identity:100%] Acetylcholinesterase C9JD78 [Target identity:44%; Query identity:100%] Acetylcholinesterase C9JUK5 [Target identity:7%; Query identity:100%] Acetylcholinesterase	Show » « Hide Potential transmembrane proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins	Show » « Hide GO:0001919 [regulation of receptor recycling] GO:0003990 [acetylcholinesterase activity] GO:0004104 [cholinesterase activity] GO:0005605 [basal lamina] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006581 [acetylcholine catabolic process] GO:0009986 [cell surface] GO:0031594 [neuromuscular junction] GO:0031623 [receptor internalization] GO:0043236 [laminin binding] GO:0043621 [protein self-association] GO:0045212 [neurotransmitter receptor biosynthetic process] GO:0051262 [protein tetramerization] GO:0060041 [retina development in camera-type eye]	359	38.6	Yes	0
ACHE-011	ENSP00000399725 ENST00000430554	C9JZL6 Show all » « Hide C9JZL6 [Target identity:100%; Query identity:100%] Acetylcholinesterase C9JD78 [Target identity:36%; Query identity:100%] Acetylcholinesterase C9JUK5 [Target identity:6%; Query identity:100%] Acetylcholinesterase	Show » « Hide Potential transmembrane proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins	Show » « Hide GO:0001919 [regulation of receptor recycling] GO:0003990 [acetylcholinesterase activity] GO:0004104 [cholinesterase activity] GO:0005605 [basal lamina] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006581 [acetylcholine catabolic process] GO:0009986 [cell surface] GO:0031594 [neuromuscular junction] GO:0031623 [receptor internalization] GO:0043236 [laminin binding] GO:0043621 [protein self-association] GO:0045212 [neurotransmitter receptor biosynthetic process] GO:0051262 [protein tetramerization] GO:0060041 [retina development in camera-type eye]	435	46.6	Yes	0
ACHE-012	ENSP00000415901 ENST00000442452	F8WD34 Show all » « Hide F8WD34 [Target identity:100%; Query identity:100%] Acetylcholinesterase C9JUK5 [Target identity:50%; Query identity:100%] Acetylcholinesterase	Show » « Hide Potential transmembrane proteins MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins	Show » « Hide GO:0001919 [regulation of receptor recycling] GO:0003990 [acetylcholinesterase activity] GO:0005605 [basal lamina] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006581 [acetylcholine catabolic process] GO:0009986 [cell surface] GO:0031594 [neuromuscular junction] GO:0031623 [receptor internalization] GO:0043236 [laminin binding] GO:0043621 [protein self-association] GO:0045212 [neurotransmitter receptor biosynthetic process] GO:0051262 [protein tetramerization] GO:0060041 [retina development in camera-type eye]	55	5.8	Yes	0
ACHE-013	ENSP00000394976 ENST00000412389	P22303 Show all » « Hide P22303 [Direct mapping] Acetylcholinesterase C9JD78 [Target identity:25%; Query identity:100%] Acetylcholinesterase C9JUK5 [Target identity:4%; Query identity:100%] Acetylcholinesterase	Show » « Hide Blood group antigen proteins Enzymes Hydrolases Potential transmembrane proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0001507 [acetylcholine catabolic process in synaptic cleft] GO:0001540 [beta-amyloid binding] GO:0001919 [regulation of receptor recycling] GO:0002076 [osteoblast development] GO:0003990 [acetylcholinesterase activity] GO:0004091 [carboxylesterase activity] GO:0004104 [cholinesterase activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005576 [extracellular region] GO:0005605 [basal lamina] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006260 [DNA replication] GO:0006581 [acetylcholine catabolic process] GO:0007155 [cell adhesion] GO:0007268 [synaptic transmission] GO:0007271 [synaptic transmission, cholinergic] GO:0007399 [nervous system development] GO:0007416 [synapse assembly] GO:0007517 [muscle organ development] GO:0008283 [cell proliferation] GO:0009611 [response to wounding] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016787 [hydrolase activity] GO:0017171 [serine hydrolase activity] GO:0019695 [choline metabolic process] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030425 [dendrite] GO:0031225 [anchored to membrane] GO:0031594 [neuromuscular junction] GO:0031623 [receptor internalization] GO:0032223 [negative regulation of synaptic transmission, cholinergic] GO:0042136 [neurotransmitter biosynthetic process] GO:0042166 [acetylcholine binding] GO:0042734 [presynaptic membrane] GO:0042803 [protein homodimerization activity] GO:0042982 [amyloid precursor protein metabolic process] GO:0043083 [synaptic cleft] GO:0043236 [laminin binding] GO:0043621 [protein self-association] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0045212 [neurotransmitter receptor biosynthetic process] GO:0048471 [perinuclear region of cytoplasm] GO:0048814 [regulation of dendrite morphogenesis] GO:0050714 [positive regulation of protein secretion] GO:0050770 [regulation of axonogenesis] GO:0051262 [protein tetramerization] GO:0060041 [retina development in camera-type eye]	614	67.8	Yes	0
ACHE-201	ENSP00000303211 ENST00000302913	P22303 Show all » « Hide P22303 [Direct mapping] Acetylcholinesterase C9JD78 [Target identity:25%; Query identity:100%] Acetylcholinesterase C9JUK5 [Target identity:4%; Query identity:100%] Acetylcholinesterase	Show » « Hide Blood group antigen proteins Enzymes Hydrolases Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins 1TM proteins predicted by MDM Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0001507 [acetylcholine catabolic process in synaptic cleft] GO:0001540 [beta-amyloid binding] GO:0001919 [regulation of receptor recycling] GO:0002076 [osteoblast development] GO:0003990 [acetylcholinesterase activity] GO:0004091 [carboxylesterase activity] GO:0004104 [cholinesterase activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005576 [extracellular region] GO:0005605 [basal lamina] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006260 [DNA replication] GO:0006581 [acetylcholine catabolic process] GO:0007155 [cell adhesion] GO:0007268 [synaptic transmission] GO:0007271 [synaptic transmission, cholinergic] GO:0007399 [nervous system development] GO:0007416 [synapse assembly] GO:0007517 [muscle organ development] GO:0008283 [cell proliferation] GO:0009611 [response to wounding] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016787 [hydrolase activity] GO:0017171 [serine hydrolase activity] GO:0019695 [choline metabolic process] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030425 [dendrite] GO:0031225 [anchored to membrane] GO:0031594 [neuromuscular junction] GO:0031623 [receptor internalization] GO:0032223 [negative regulation of synaptic transmission, cholinergic] GO:0042136 [neurotransmitter biosynthetic process] GO:0042166 [acetylcholine binding] GO:0042734 [presynaptic membrane] GO:0042803 [protein homodimerization activity] GO:0042982 [amyloid precursor protein metabolic process] GO:0043083 [synaptic cleft] GO:0043236 [laminin binding] GO:0043621 [protein self-association] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0045212 [neurotransmitter receptor biosynthetic process] GO:0048471 [perinuclear region of cytoplasm] GO:0048814 [regulation of dendrite morphogenesis] GO:0050714 [positive regulation of protein secretion] GO:0050770 [regulation of axonogenesis] GO:0051262 [protein tetramerization] GO:0060041 [retina development in camera-type eye]	617	67.4	Yes	1

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.