ACHE

GENE INFORMATION

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Gene name

ACHE (HGNC Symbol)

Synonyms

YT

Description

acetylcholinesterase (HGNC Symbol)

Entrez gene summary

Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq, Jul 2008]

Chromosome

7 (Chromosome progress)

Cytoband

q22.1

Chromosome location (bp)

100487615 - 100494594

Ensembl

ENSG00000087085 (version 73.37)

Entrez gene

43

UniProt

P22303 (UniProt - Evidence at protein level)

neXtProt

NX_P22303

Antibodypedia

ACHE antibodies
 

PROTEIN VIEW

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 « 
 
ACHE-001
 
ACHE-002
 
ACHE-003
 
ACHE-004
 
ACHE-006
 
ACHE-007
 
ACHE-008
 
ACHE-009
 
ACHE-010
 
ACHE-011
 
ACHE-012
 
ACHE-013
 
ACHE-201
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACHE-001 ENSP00000241069
ENST00000241069
P22303
Show all »
Show » Show » 614 67.8 Yes 0
ACHE-002 ENSP00000403474
ENST00000419336
P22303
Show all »
Show » Show » 526 58.4 Yes 0
ACHE-003 ENSP00000404865
ENST00000411582
P22303
Show all »
Show » Show » 617 67.4 Yes 1
ACHE-004 ENSP00000400933
ENST00000445236
C9JUK5
Show all »
Show » Show » 28 3 No 0
ACHE-006 ENSP00000414858
ENST00000428317
P22303
Show all »
Show » Show » 614 67.8 Yes 0
ACHE-007 ENSP00000396360
ENST00000441605
C9JD78
Show all »
Show » Show » 159 17.4 Yes 0
ACHE-008 ENSP00000397143
ENST00000426415
C9J2S3
Show all »
Show » Show » 398 42.6 Yes 0
ACHE-009 ENSP00000390004
ENST00000454485
F8WD68
Show all »
Show » Show » 403 43.3 Yes 0
ACHE-010 ENSP00000410380
ENST00000440755
F8WAR7
Show all »
Show » Show » 359 38.6 Yes 0
ACHE-011 ENSP00000399725
ENST00000430554
C9JZL6
Show all »
Show » Show » 435 46.6 Yes 0
ACHE-012 ENSP00000415901
ENST00000442452
F8WD34
Show all »
Show » Show » 55 5.8 Yes 0
ACHE-013 ENSP00000394976
ENST00000412389
P22303
Show all »
Show » Show » 614 67.8 Yes 0
ACHE-201 ENSP00000303211
ENST00000302913
P22303
Show all »
Show » Show » 617 67.4 Yes 1