BAX

GENE INFORMATION

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Gene name

BAX (HGNC Symbol)

Synonyms

BCL2L4

Description

BCL2-associated X protein (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008]

Chromosome

19 (Chromosome progress)

Cytoband

q13.33

Chromosome location (bp)

49458072 - 49465055

Ensembl

ENSG00000087088 (version 73.37)

Entrez gene

581

UniProt

Q07812 (UniProt - Evidence at protein level)

neXtProt

NX_Q07812

Antibodypedia

BAX antibodies
 

PROTEIN VIEW

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BAX-001
 
BAX-002
 
BAX-003
 
BAX-004
 
BAX-005
 
BAX-006
 
BAX-007
 
BAX-201
 
BAX-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BAX-001 ENSP00000293288
ENST00000293288
Q07812
Show all »
Show » Show » 218 24.2 No 0
BAX-002 ENSP00000348871
ENST00000356483
Q07812
Show all »
Show » Show » 164 18.1 No 0
BAX-003 ENSP00000389971
ENST00000415969
Q07812
Show all »
Show » Show » 179 19.7 No 0
BAX-004 ENSP00000426184
ENST00000506183
Q9UEI8
Show all »
Show » Show » 126 14.1 No 0
BAX-005 ENSP00000346461
ENST00000354470
Q07812
Show all »
Show » Show » 143 15.8 No 0
BAX-006 ENSP00000263262
ENST00000345358
Q07812
Show all »
Show » Show » 192 21.2 No 0
BAX-007 ENSP00000426328
ENST00000515540
Q07812
Show all »
Show » Show » 41 4.7 No 0
BAX-201 ENSP00000375744
ENST00000391871
Q07812
Show all »
Show » Show » 41 4.7 No 0
BAX-202 ENSP00000441413
ENST00000539787
Q07812
Show all »
Show » Show » 164 18.1 No 0