ADAMTS2

GENE INFORMATION

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Gene name

ADAMTS2 (HGNC Symbol)

Synonyms

ADAM-TS2, ADAMTS-3, hPCPNI, NPI, PCINP

Description

ADAM metallopeptidase with thrombospondin type 1 motif, 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene excises the N-propeptide of type I, type II and type V procollagens. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

Chromosome

5 (Chromosome progress)

Cytoband

q35.3

Chromosome location (bp)

178537852 - 178772431

Ensembl

ENSG00000087116 (version 73.37)

Entrez gene

9509

UniProt

O95450 (UniProt - Evidence at transcript level)

neXtProt

NX_O95450

Antibodypedia

ADAMTS2 antibodies
 

PROTEIN VIEW

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ADAMTS2-001
 
ADAMTS2-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADAMTS2-001 ENSP00000251582
ENST00000251582
O95450
Show all »
Show » Show » 1211 134.8 Yes 0
ADAMTS2-002 ENSP00000274609
ENST00000274609
O95450
Show all »
Show » Show » 566 61.8 Yes 0