SH3BP2

GENERAL INFORMATION

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Gene name

SH3BP2

Gene description

SH3-domain binding protein 2

Protein class

Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

12
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most of the normal tissues displayed moderate to strong cytoplasmic positivity.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA036790
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Lung

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

SH3BP2 (HGNC Symbol)

Synonyms

CRBM, RES4-23

Description

SH3-domain binding protein 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Chromosome

4

Cytoband

p16.3

Chromosome location (bp)

2793023 - 2841098

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000087266 (version 78.38)

Entrez gene

6452

UniProt

P78314 (UniProt - Evidence at protein level)

neXtProt

NX_P78314

Antibodypedia

SH3BP2 antibodies


PROTEIN BROWSER

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ENST00000356331
 
ENST00000435136
 
ENST00000442312
 
ENST00000452765
 
ENST00000502260
 
ENST00000503219
 
ENST00000503393
 
ENST00000504294
 
ENST00000508385
 
ENST00000511747
 
ENST00000512014
 
ENST00000513095
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SH3BP2-001 ENSP00000409746
ENST00000452765
P78314
Show all »
Show » Show » 561 62.2 No 0
SH3BP2-002 ENSP00000403231
ENST00000435136
P78314
Show all »
Show » Show » 561 62.2 No 0
SH3BP2-006 ENSP00000424846
ENST00000511747
P78314
Show all »
Show » Show » 561 62.2 No 0
SH3BP2-007 ENSP00000348685
ENST00000356331
P78314
Show all »
Show » Show » 561 62.2 No 0
SH3BP2-010 ENSP00000422796
ENST00000503219
D6RAB4
Show all »
Show » 142 16.3 No 0
SH3BP2-012 ENSP00000423275
ENST00000504294
D6R995
Show all »
Show » 172 19.5 No 0
SH3BP2-014 ENSP00000424917
ENST00000508385
D6RER9
Show all »
Show » 188 21.4 No 0
SH3BP2-017 ENSP00000424105
ENST00000512014
D6RBL6
Show all »
Show » 194 22.1 No 0
SH3BP2-018 ENSP00000423823
ENST00000513095
D6RC64
Show all »
Show » 136 15.6 No 0
SH3BP2-019 ENSP00000425537
ENST00000502260
D6RAB4
Show all »
Show » 142 16.3 No 0
SH3BP2-201 ENSP00000388152
ENST00000442312
P78314
Show all »
Show » Show » 589 65.3 No 0
SH3BP2-202 ENSP00000422168
ENST00000503393
P78314
Show all »
Show » Show » 618 68.1 No 0