SF3B2

GENERAL INFORMATION

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Gene name

SF3B2

Gene description

Splicing factor 3b, subunit 2, 145kDa

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

8
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous nuclear expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
HPA045028
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

SF3B2 (HGNC Symbol)

Synonyms

Cus1, SAP145, SF3b1, SF3b145

Description

Splicing factor 3b, subunit 2, 145kDa (HGNC Symbol)

Entrez gene summary

This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q13.1

Chromosome location (bp)

66050729 - 66069308

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000087365 (version 78.38)

Entrez gene

10992

UniProt

Q13435 (UniProt - Evidence at protein level)

neXtProt

NX_Q13435

Antibodypedia

SF3B2 antibodies


PROTEIN BROWSER

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ENST00000322535
 
ENST00000524475
 
ENST00000524627
 
ENST00000528302
 
ENST00000530322
 
ENST00000530981
 
ENST00000533595
 
ENST00000610523
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SF3B2-001 ENSP00000318861
ENST00000322535
Q13435
Show all »
Show » Show » 895 100.2 No 0
SF3B2-006 ENSP00000432655
ENST00000528302
E9PPJ0
Show all »
Show » Show » 878 98.2 No 0
SF3B2-009 ENSP00000435765
ENST00000524475
E9PIL8
Show all »
Show » 81 8.5 No 0
SF3B2-012 ENSP00000431908
ENST00000533595
E9PJ04
Show all »
Show » Show » 354 38.6 No 0
SF3B2-015 ENSP00000436757
ENST00000530981
Show » 315 34.9 No 0
SF3B2-018 ENSP00000431520
ENST00000530322
H0YCG1
Show all »
Show » Show » 387 42.5 No 0
SF3B2-019 ENSP00000435495
ENST00000524627
E9PJT3
Show all »
Show » Show » 273 29.1 No 0
SF3B2-201 ENSP00000482986
ENST00000610523
E9PIL8
Show all »
Show » Show » 871 97.6 No 0