SF3B2

GENE INFORMATION

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Gene name

SF3B2 (HGNC Symbol)

Synonyms

Cus1, SAP145, SF3b1, SF3b145

Description

splicing factor 3b, subunit 2, 145kDa (HGNC Symbol)

Entrez gene summary

This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus. [provided by RefSeq, Jul 2008]

Chromosome

11 (Chromosome progress)

Cytoband

q13.1

Chromosome location (bp)

65818200 - 65836779

Ensembl

ENSG00000087365 (version 73.37)

Entrez gene

10992

UniProt

Q13435 (UniProt - Evidence at protein level)

neXtProt

NX_Q13435

Antibodypedia

SF3B2 antibodies
 

PROTEIN VIEW

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SF3B2-001
 
SF3B2-006
 
SF3B2-009
 
SF3B2-012
 
SF3B2-015
 
SF3B2-018
 
SF3B2-019
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SF3B2-001 ENSP00000318861
ENST00000322535
Q13435
Show all »
Show » 895 100.2 No 0
SF3B2-006 ENSP00000432655
ENST00000528302
E9PPJ0
Show all »
Show » 878 98.2 No 0
SF3B2-009 ENSP00000435765
ENST00000524475
E9PIL8
Show all »
81 8.5 No 0
SF3B2-012 ENSP00000431908
ENST00000533595
E9PJ04
Show all »
Show » 354 38.6 No 0
SF3B2-015 ENSP00000436757
ENST00000530981
315 34.9 No 0
SF3B2-018 ENSP00000431520
ENST00000530322
H0YCG1
Show all »
Show » 387 42.5 No 0
SF3B2-019 ENSP00000435495
ENST00000524627
E9PJT3
Show all »
Show » 273 29.1 No 0