FKBP1A

GENERAL INFORMATION

? »

Gene name

FKBP1A

Gene description

FK506 binding protein 1A, 12kDa

Protein class

Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression at variable levels in several different cell types.

ANTIBODY RELIABILITY

? »

Data reliability
description

Pending RNA-based expert annotation. Caution, targets protein from more than one gene.

Data reliability

Uncertain based on 2 antibodies.
HPA051798 , CAB004639
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

? »

Gene name

FKBP1A (HGNC Symbol)

Synonyms

FKBP-12, FKBP1, FKBP12, FKBP12C, PKC12, PPIASE

Description

FK506 binding protein 1A, 12kDa (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq, Sep 2008]

Chromosome

20

Cytoband

p13

Chromosome location (bp)

1368978 - 1393172

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000088832 (version 78.38)

Entrez gene

2280

UniProt

P62942 (UniProt - Evidence at protein level)

neXtProt

NX_P62942

Antibodypedia

FKBP1A antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000381715
 
ENST00000381719
 
ENST00000381724
 
ENST00000400137
 
ENST00000439640
 
ENST00000614856
 
ENST00000618612
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FKBP1A-001 ENSP00000383003
ENST00000400137
P62942
Show all »
Show » Show » 108 12 No 0
FKBP1A-002 ENSP00000371138
ENST00000381719
P62942
Show all »
Show » Show » 108 12 No 0
FKBP1A-004 ENSP00000371143
ENST00000381724
Q5W0X3
Show all »
Show » Show » 103 11.4 No 0
FKBP1A-005 ENSP00000371134
ENST00000381715
Q5W0X3
Show all »
Show » Show » 103 11.4 No 0
FKBP1A-009 ENSP00000482758
ENST00000614856
Q9UH88
Show all »
Show » Show » 129 14.9 No 1
FKBP1A-201 ENSP00000409863
ENST00000439640
Q1JUQ5
Show all »
Show » Show » 92 10.1 No 0
FKBP1A-202 ENSP00000478093
ENST00000618612
Show » 97 10.8 No 0