FKBP1A

GENE INFORMATION

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Gene name

FKBP1A (HGNC Symbol)

Synonyms

FKBP-12, FKBP1, FKBP12, FKBP12C, PKC12, PPIASE

Description

FK506 binding protein 1A, 12kDa (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq, Sep 2008]

Chromosome

20 (Chromosome progress)

Cytoband

p13

Chromosome location (bp)

1349622 - 1373806

Ensembl

ENSG00000088832 (version 73.37)

Entrez gene

2280

UniProt

P62942 (UniProt - Evidence at protein level)

neXtProt

NX_P62942

Antibodypedia

FKBP1A antibodies
 

PROTEIN VIEW

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FKBP1A-001
 
FKBP1A-002
 
FKBP1A-004
 
FKBP1A-005
 
FKBP1A-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FKBP1A-001 ENSP00000383003
ENST00000400137
P62942
Show all »
Show » Show » 108 12 No 0
FKBP1A-002 ENSP00000371138
ENST00000381719
P62942
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Show » Show » 108 12 No 0
FKBP1A-004 ENSP00000371143
ENST00000381724
Q5W0X3
Show all »
Show » 103 11.4 No 0
FKBP1A-005 ENSP00000371134
ENST00000381715
Q5W0X3
Show all »
Show » 103 11.4 No 0
FKBP1A-201 ENSP00000409863
ENST00000439640
Q1JUQ5
Show all »
Show » 92 10.1 No 0