F11

GENE INFORMATION

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Gene name

F11 (HGNC Symbol)

Synonyms

FXI

Description

coagulation factor XI (HGNC Symbol)

Entrez gene summary

This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]

Chromosome

4 (Chromosome progress)

Cytoband

q35.2

Chromosome location (bp)

187187099 - 187210835

Ensembl

ENSG00000088926 (version 73.37)

Entrez gene

2160

UniProt

P03951 (UniProt - Evidence at protein level)

neXtProt

NX_P03951

Antibodypedia

F11 antibodies
 

PROTEIN VIEW

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F11-001
 
F11-002
 
F11-003
 
F11-007
 
F11-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

F11-001 ENSP00000384957
ENST00000403665
P03951
Show all »
Show » Show » 625 70.1 Yes 0
F11-002 ENSP00000424479
ENST00000492972
D6RB32
Show all »
Show » Show » 162 18.5 Yes 0
F11-003 ENSP00000397401
ENST00000452239
Q9UEG0
Show all »
Show » 210 23 No 0
F11-007 ENSP00000264691
ENST00000264691
Show » 159 17.9 No 0
F11-201 ENSP00000264692
ENST00000264692
E9PGP2
Show all »
Show » Show » 573 64.1 Yes 0