MAPKAPK5

GENE INFORMATION

? »

Gene name

MAPKAPK5 (HGNC Symbol)

Synonyms

PRAK

Description

mitogen-activated protein kinase-activated protein kinase 5 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]

Chromosome

12 (Chromosome progress)

Cytoband

q24.12

Chromosome location (bp)

112279782 - 112334343

Ensembl

ENSG00000089022 (version 73.37)

Entrez gene

8550

UniProt

Q8IW41 (UniProt - Evidence at protein level)

neXtProt

NX_Q8IW41

Antibodypedia

MAPKAPK5 antibodies
 

PROTEIN VIEW

? »
 
 
 
MAPKAPK5-001
 
MAPKAPK5-002
 
MAPKAPK5-003
 
MAPKAPK5-004
 
MAPKAPK5-005
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAPKAPK5-001 ENSP00000449667
ENST00000550735
Show » Show » 471 54 No 1
MAPKAPK5-002 ENSP00000449381
ENST00000551404
Q8IW41
Show all »
Show » Show » 473 54.2 No 1
MAPKAPK5-003 ENSP00000473541
ENST00000547305
R4GN93
Show all »
51 5.9 No 0
MAPKAPK5-004 ENSP00000448408
ENST00000553053
F8VRP2
Show all »
Show » 74 8.3 No 0
MAPKAPK5-005 ENSP00000473467
ENST00000549875
R4GN33
Show all »
Show » Show » 324 37.1 No 1