P2RX7

GENE INFORMATION

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Gene name

P2RX7 (HGNC Symbol)

Synonyms

MGC20089, P2X7

Description

purinergic receptor P2X, ligand-gated ion channel, 7 (HGNC Symbol)

Entrez gene summary

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010]

Chromosome

12 (Chromosome progress)

Cytoband

q24.31

Chromosome location (bp)

121570622 - 121623876

Ensembl

ENSG00000089041 (version 73.37)

Entrez gene

5027

UniProt

Q99572 (UniProt - Evidence at protein level)

neXtProt

NX_Q99572

Antibodypedia

P2RX7 antibodies
 

PROTEIN VIEW

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 « 
 
P2RX7-003
 
P2RX7-004
 
P2RX7-005
 
P2RX7-007
 
P2RX7-008
 
P2RX7-009
 
P2RX7-010
 
P2RX7-011
 
P2RX7-012
 
P2RX7-013
 
P2RX7-015
 
P2RX7-201
 
P2RX7-202
 
P2RX7-203
 
P2RX7-204
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

P2RX7-003 ENSP00000445325
ENST00000539606
F5H2X6
Show all »
Show » Show » 127 14.7 No 1
P2RX7-004 ENSP00000438586
ENST00000537312
F5H237
Show all »
Show » Show » 47 5.5 No 1
P2RX7-005 ENSP00000442470
ENST00000535600
E7EMK6
Show all »
Show » Show » 275 31.3 No 2
P2RX7-007 ENSP00000437729
ENST00000541716
Q4VKI3
Show all »
Show » Show » 128 14.7 No 1
P2RX7-008 ENSP00000442349
ENST00000546057
Q99572
Show all »
Show » Show » 595 68.6 No 2
P2RX7-009 ENSP00000441230
ENST00000541022
Q4VKI3
Show all »
Show » Show » 128 14.7 No 1
P2RX7-010 ENSP00000443640
ENST00000541564
F5H8E7
Show all »
Show » Show » 258 29.3 No 1
P2RX7-011 ENSP00000261826
ENST00000261826
J3KN30
Show all »
Show » Show » 149 17.1 No 1
P2RX7-012 ENSP00000439247
ENST00000538011
F5H2X6
Show all »
Show » Show » 127 14.7 No 1
P2RX7-013 ENSP00000445564
ENST00000545434
F5H237
Show all »
Show » Show » 47 5.5 No 1
P2RX7-015 ENSP00000439961
ENST00000535928
F5H237
Show all »
Show » Show » 47 5.5 No 1
P2RX7-201 ENSP00000330696
ENST00000328963
F8W951
Show all »
Show » Show » 425 49.2 No 1
P2RX7-202 ENSP00000366367
ENST00000377162
E7EMK6
Show all »
Show » Show » 275 31.3 No 2
P2RX7-203 ENSP00000442572
ENST00000535250
F5H7E8
Show all »
Show » Show » 505 58.2 No 1
P2RX7-204 ENSP00000437471
ENST00000541446
F5H6P2
Show all »
Show » Show » 306 35.5 No 1