FUS

GENE INFORMATION

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Gene name

FUS (HGNC Symbol)

Synonyms

ALS6, FUS1, hnRNP-P2, HNRNPP2, TLS

Description

fused in sarcoma (HGNC Symbol)

Entrez gene summary

This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]

Chromosome

16 (Chromosome progress)

Cytoband

p11.2

Chromosome location (bp)

31191431 - 31203127

Ensembl

ENSG00000089280 (version 73.37)

Entrez gene

2521

UniProt

P35637 (UniProt - Evidence at protein level)

neXtProt

NX_P35637

Antibodypedia

FUS antibodies
 

PROTEIN VIEW

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FUS-001
 
FUS-008
 
FUS-010
 
FUS-016
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FUS-001 ENSP00000254108
ENST00000254108
P35637
Show all »
Show » Show » 526 53.4 No 0
FUS-008 ENSP00000369594
ENST00000380244
P35637
Show all »
Show » Show » 525 53.4 No 0
FUS-010 ENSP00000455073
ENST00000566605
H3BNZ4
Show all »
Show » 263 25.9 No 0
FUS-016 ENSP00000455282
ENST00000568685
H3BPE7
Show all »
Show » Show » 527 53.5 No 0