IRAK3

GENE INFORMATION

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Gene name

IRAK3 (HGNC Symbol)

Synonyms

IRAK-M

Description

interleukin-1 receptor-associated kinase 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Chromosome

12 (Chromosome progress)

Cytoband

q14.3

Chromosome location (bp)

66582659 - 66648402

Ensembl

ENSG00000090376 (version 73.37)

Entrez gene

11213

UniProt

Q9Y616 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y616

Antibodypedia

IRAK3 antibodies
 

PROTEIN VIEW

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IRAK3-001
 
IRAK3-002
 
IRAK3-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IRAK3-001 ENSP00000261233
ENST00000261233
Q9Y616
Show all »
Show » Show » 596 67.8 No 0
IRAK3-002 ENSP00000441321
ENST00000545837
F5GYN6
Show all »
93 10 Yes 0
IRAK3-003 ENSP00000409852
ENST00000457197
Q9Y616
Show all »
Show » Show » 535 60.6 Yes 0