THPO

GENE INFORMATION

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Gene name

THPO (HGNC Symbol)

Synonyms

MGDF, MPLLG, TPO

Description

Thrombopoietin (HGNC Symbol)

Entrez gene summary

Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014]

Chromosome

3

Cytoband

q27.1

Chromosome location (bp)

184089723 - 184095932

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000090534 (version 75.37)

Entrez gene

7066

UniProt

P40225 (UniProt - Evidence at protein level)

neXtProt

NX_P40225

Antibodypedia

THPO antibodies
 

PROTEIN VIEW

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THPO-001
 
THPO-002
 
THPO-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

THPO-001 ENSP00000204615
ENST00000204615
P40225
Show all »
Show » Show » 353 37.8 Yes 0
THPO-002 ENSP00000410763
ENST00000445696
P40225
Show all »
Show » Show » 349 37.4 Yes 0
THPO-003 ENSP00000411704
ENST00000421442
F8W6L1
Show all »
Show » Show » 286 31.5 Yes 0