THPO

GENE INFORMATION

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Gene name

THPO (HGNC Symbol)

Synonyms

MGDF, MPLLG, TPO

Description

thrombopoietin (HGNC Symbol)

Entrez gene summary

Megakaryocytopoiesis is the cellular development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternate splicing results in multiple transcript variants of this gene.[provided by RefSeq, Jun 2012]

Chromosome

3 (Chromosome progress)

Cytoband

q27.1

Chromosome location (bp)

184089723 - 184095932

Ensembl

ENSG00000090534 (version 73.37)

Entrez gene

7066

UniProt

P40225 (UniProt - Evidence at protein level)

neXtProt

NX_P40225

Antibodypedia

THPO antibodies
 

PROTEIN VIEW

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THPO-001
 
THPO-002
 
THPO-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

THPO-001 ENSP00000204615
ENST00000204615
P40225
Show all »
Show » Show » 353 37.8 Yes 0
THPO-002 ENSP00000410763
ENST00000445696
P40225
Show all »
Show » Show » 349 37.4 Yes 0
THPO-003 ENSP00000411704
ENST00000421442
F8W6L1
Show all »
Show » Show » 286 31.5 Yes 0