CD209

GENE INFORMATION

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Gene name

CD209 (HGNC Symbol)

Synonyms

CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1

Description

CD209 molecule (HGNC Symbol)

Entrez gene summary

This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]

Chromosome

19 (Chromosome progress)

Cytoband

p13.2

Chromosome location (bp)

7804879 - 7812464

Ensembl

ENSG00000090659 (version 73.37)

Entrez gene

30835

UniProt

Q9NNX6 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NNX6

Antibodypedia

CD209 antibodies
 

PROTEIN VIEW

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CD209-001
 
CD209-002
 
CD209-003
 
CD209-004
 
CD209-005
 
CD209-006
 
CD209-007
 
CD209-008
 
CD209-009
 
CD209-012
 
CD209-014
 
CD209-201
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CD209-001 ENSP00000315477
ENST00000315599
Q9NNX6
Show all »
Show » Show » 404 45.8 No 1
CD209-002 ENSP00000346373
ENST00000354397
Q9NNX6
Show all »
Show » Show » 398 45 No 1
CD209-003 ENSP00000468827
ENST00000601951
Q9NNX6
Show all »
Show » Show » 380 43.1 No 0
CD209-004 ENSP00000471348
ENST00000593821
M0R0P0
Show all »
Show » 268 30.5 No 0
CD209-005 ENSP00000315407
ENST00000315591
Q9NNX6
Show all »
Show » Show » 380 43.3 No 0
CD209-006 ENSP00000471137
ENST00000602261
Q9NNX6
Show all »
Show » Show » 312 35.2 No 1
CD209-007 ENSP00000470530
ENST00000593660
M0QZG5
Show all »
Show » 334 37.9 No 0
CD209-008 ENSP00000470658
ENST00000601256
Q9NNX6
Show all »
Show » Show » 297 33.9 No 0
CD209-009 ENSP00000377728
ENST00000394173
B4E2A8
Show all »
Show » Show » 243 27.4 No 1
CD209-012 ENSP00000377716
ENST00000394161
Q9NNX6
Show all »
Show » Show » 168 18.6 No 1
CD209-014 ENSP00000204801
ENST00000204801
Q9NNX6
Show all »
Show » Show » 360 41 No 0
CD209-201 ENSP00000301357
ENST00000301357
Q9NNX6
Show all »
Show » Show » 268 30.4 No 0