MLTK

GENE INFORMATION

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Gene name

MLTK

Synonyms

Description

Mitogen-activated protein kinase kinase kinase MLT (UniProtKB/Swiss-Prot)

Entrez gene summary

This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

2 (Chromosome progress)

Cytoband

q31.1

Chromosome location (bp)

173940163 - 174132738

Ensembl

ENSG00000091436 (version 73.37)

Entrez gene

51776

UniProt

Q9NYL2 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NYL2

Antibodypedia

MLTK antibodies
 

PROTEIN VIEW

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MLTK-001
 
MLTK-002
 
MLTK-003
 
MLTK-006
 
MLTK-201
 
MLTK-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MLTK-001 ENSP00000364361
ENST00000375213
Q9NYL2
Show all »
Show » Show » 800 91.2 No 0
MLTK-002 ENSP00000340257
ENST00000338983
D4Q8H0
Show all »
Show » 455 51.6 No 0
MLTK-003 ENSP00000387259
ENST00000409176
Q9NYL2
Show all »
Show » Show » 800 91.2 No 0
MLTK-006 ENSP00000411923
ENST00000422149
C9J3F7
Show all »
Show » 138 15.8 No 0
MLTK-201 ENSP00000399787
ENST00000431503
B4DQ47
Show all »
Show » 354 40.2 No 0
MLTK-202 ENSP00000439414
ENST00000539448
D4Q8H0
Show all »
Show » 455 51.6 No 0