ORC6

GENE INFORMATION

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Gene name

ORC6 (HGNC Symbol)

Synonyms

ORC6L

Description

origin recognition complex, subunit 6 (HGNC Symbol)

Entrez gene summary

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010]

Chromosome

16 (Chromosome progress)

Cytoband

q11.2

Chromosome location (bp)

46723555 - 46732306

Ensembl

ENSG00000091651 (version 73.37)

Entrez gene

23594

UniProt

Q9Y5N6 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y5N6

Antibodypedia

ORC6 antibodies
 

PROTEIN VIEW

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ORC6-001
 
ORC6-004
 
ORC6-005
 
ORC6-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ORC6-001 ENSP00000219097
ENST00000219097
Q9Y5N6
Show all »
Show » 252 28.1 No 0
ORC6-004 ENSP00000454299
ENST00000563599
H3BMA4
Show all »
Show » 36 3.8 No 0
ORC6-005 ENSP00000456981
ENST00000566860
H3BT22
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Show » 203 22.8 No 0
ORC6-006 ENSP00000457282
ENST00000568364
H3BTQ7
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Show » 167 18.5 No 0