ESR1

GENE INFORMATION

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Gene name

ESR1 (HGNC Symbol)

Synonyms

Era, ESR, NR3A1

Description

estrogen receptor 1 (HGNC Symbol)

Entrez gene summary

This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. [provided by RefSeq, Jul 2008]

Chromosome

6 (Chromosome progress)

Cytoband

q25.1

Chromosome location (bp)

151977826 - 152450754

Ensembl

ENSG00000091831 (version 73.37)

Entrez gene

2099

UniProt

P03372 (UniProt - Evidence at protein level)

neXtProt

NX_P03372

Antibodypedia

ESR1 antibodies
 

PROTEIN VIEW

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 « 
 
ESR1-001
 
ESR1-002
 
ESR1-004
 
ESR1-007
 
ESR1-008
 
ESR1-009
 
ESR1-010
 
ESR1-201
 
ESR1-202
 
ESR1-203
 
ESR1-204
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ESR1-001 ENSP00000206249
ENST00000206249
P03372
Show all »
Show » Show » 595 66.2 No 0
ESR1-002 ENSP00000342630
ENST00000338799
P03372
Show all »
Show » Show » 595 66.2 No 0
ESR1-004 ENSP00000385373
ENST00000404742
Q5T5H8
Show all »
Show » Show » 84 9 No 0
ESR1-007 ENSP00000411105
ENST00000446550
Q9UE35
Show all »
Show » Show » 115 12.1 No 0
ESR1-008 ENSP00000394721
ENST00000427531
F6SD09
Show all »
Show » Show » 388 43.4 No 0
ESR1-009 ENSP00000384064
ENST00000406599
Q9H2M1
Show all »
Show » Show » 334 36.7 No 0
ESR1-010 ENSP00000401995
ENST00000415488
B0QYW7
Show all »
Show » Show » 107 12.3 No 0
ESR1-201 ENSP00000405330
ENST00000440973
P03372
Show all »
Show » Show » 595 66.2 No 0
ESR1-202 ENSP00000387500
ENST00000443427
P03372
Show all »
Show » Show » 595 66.2 No 0
ESR1-203 ENSP00000415934
ENST00000456483
P03372
Show all »
Show » Show » 483 53.7 No 0
ESR1-204 ENSP00000445454
ENST00000544394
F6SD09
Show all »
Show » Show » 310 35.3 No 0