|
|
|
GENE INFORMATION
? »
|
The gene information section lists the gene name (HUGO Gene Nomenclature Committee ( HGNC) name if available), any approved gene synonyms, Ensembl gene description, and the Entrez gene summary from the National Center for Biotechnology Information.
The chromosomal and cytoband location of the gene according to Ensembl is reported together with the Ensembl gene identifier and Ensembl database version. The Entrez gene identifier for the gene is also given. If any of the protein products of the gene is linked to a UniProt KB/SWISS-PROT entry, links to the UniProt and the neXtProt databases for these proteins are displayed.
|
Gene name |
ESR1 (HGNC Symbol) |
Synonyms |
Era, ESR, NR3A1 |
Description |
estrogen receptor 1 (HGNC Symbol) |
Entrez gene summary |
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. [provided by RefSeq, Jul 2008] |
Chromosome |
6 (Chromosome progress)
|
Cytoband |
q25.1 |
Chromosome location (bp) |
151977826 - 152450754 |
Ensembl |
ENSG00000091831 (version 69.37) |
Entrez gene |
2099 |
UniProt |
P03372 |
neXtProt |
NX_P03372 |
Antibodypedia |
ESR1 antibodies |
|
| |
|
|
PROTEIN VIEW
? »
|
The protein view displays protein features. The tabs at the top of the protein view section can be used to switch between the different splice variants encoded by this gene. The mouse over function displays additional data for the features in the protein view.
At the top of the protein view, the maximum percent sequence identity of the protein to all other proteins from other human genes is shown, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) ( read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green.
Common (purple) and unique (grey) regions between alternative processed transcripts from the same gene are also displayed ( read more), and at the bottom of the protein view is the protein scale.
|
|
|
| |
|
|
PROTEIN INFORMATION
? »
|
The protein information section displays the alternative protein-coding transcripts (splice variants) encoded by this gene, according to the Ensembl database.
The ENSP identifier links to the Ensembl website for that protein, and the ENST identifier links to the Ensembl website for that transcript. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes to which this protein has been assigned are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column.
The length of the protein (amino acid residues) (according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius and predicted transmembrane region(s) (according to MDM) are also reported.
|
Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length (aa) |
Molecular mass (kDa) |
Signal peptide (predicted) |
Transmembrane regions (predicted)
|
| ESR1-001 |
ENSP00000206249
ENST00000206249
|
P03372 Show all »
« Hide
P03372 [Direct mapping]Estrogen receptor G4XH65 [Target identity:100%; Query identity:100%]Estrogen nuclear receptor alpha E3WH18 [Target identity:31%; Query identity:100%]Estrogen receptor alpha Q9UE35 [Target identity:19%; Query identity:100%]Estrogen receptor; Estrogen receptor 1; Estrogen receptor protein Q5T5H8 [Target identity:14%; Query identity:100%]Estrogen receptor; Estrogen receptor 1 B6DU67 [Target identity:7%; Query identity:100%]Estrogen receptor alpha delta 3*,4,5,6,7*/775 hypothalamic isoform C7FFR5 [Target identity:7%; Query identity:100%]Estrogen receptor alpha 3*,4,5,6,7*/765 isoform C8CJL0 [Target identity:4%; Query identity:100%]Estrogen receptor alpha delta 2*,3,4,5,6,7 isoform Q9UBT1 [Target identity:3%; Query identity:100%]Estrogen receptor
|
Show »
« Hide
Candidate cancer biomarkers Transcription factors Potential transmembrane proteins THUMBUP predicted membrane proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level
|
Show »
« Hide
|
595 |
66.2 |
No |
0 |
| ESR1-002 |
ENSP00000342630
ENST00000338799
|
P03372 Show all »
« Hide
P03372 [Direct mapping]Estrogen receptor G4XH65 [Target identity:100%; Query identity:100%]Estrogen nuclear receptor alpha E3WH18 [Target identity:31%; Query identity:100%]Estrogen receptor alpha Q9UE35 [Target identity:19%; Query identity:100%]Estrogen receptor; Estrogen receptor 1; Estrogen receptor protein Q5T5H8 [Target identity:14%; Query identity:100%]Estrogen receptor; Estrogen receptor 1 B6DU67 [Target identity:7%; Query identity:100%]Estrogen receptor alpha delta 3*,4,5,6,7*/775 hypothalamic isoform C7FFR5 [Target identity:7%; Query identity:100%]Estrogen receptor alpha 3*,4,5,6,7*/765 isoform C8CJL0 [Target identity:4%; Query identity:100%]Estrogen receptor alpha delta 2*,3,4,5,6,7 isoform Q9UBT1 [Target identity:3%; Query identity:100%]Estrogen receptor
|
Show »
« Hide
Candidate cancer biomarkers Transcription factors Potential transmembrane proteins THUMBUP predicted membrane proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level
|
Show »
« Hide
|
595 |
66.2 |
No |
0 |
| ESR1-004 |
ENSP00000385373
ENST00000404742
|
Q5T5H8 Show all »
« Hide
Q5T5H8 [Target identity:100%; Query identity:100%]Estrogen receptor; Estrogen receptor 1 Q9UBT1 [Target identity:27%; Query identity:100%]Estrogen receptor
|
Show »
« Hide
Transcription factors
|
Show »
« Hide
|
84 |
9 |
No |
0 |
| ESR1-007 |
ENSP00000411105
ENST00000446550
|
Q9UE35 Show all »
« Hide
Q9UE35 [Target identity:100%; Query identity:100%]Estrogen receptor; Estrogen receptor 1; Estrogen receptor protein Q5T5H8 [Target identity:73%; Query identity:100%]Estrogen receptor; Estrogen receptor 1 Q9UBT1 [Target identity:20%; Query identity:100%]Estrogen receptor
|
Show »
« Hide
Transcription factors
|
Show »
« Hide
|
115 |
12.1 |
No |
0 |
| ESR1-008 |
ENSP00000394721
ENST00000427531
|
B0QYW6 Show all »
« Hide
B0QYW6 [Target identity:99%; Query identity:100%]Estrogen receptor 1 F6SD09 [Target identity:79%; Query identity:100%]Estrogen receptor B6DU67 [Target identity:11%; Query identity:100%]Estrogen receptor alpha delta 3*,4,5,6,7*/775 hypothalamic isoform C7FFR5 [Target identity:11%; Query identity:100%]Estrogen receptor alpha 3*,4,5,6,7*/765 isoform C8CJL0 [Target identity:6%; Query identity:100%]Estrogen receptor alpha delta 2*,3,4,5,6,7 isoform
|
Show »
« Hide
Transcription factors Potential transmembrane proteins THUMBUP predicted membrane proteins
|
Show »
« Hide
|
388 |
43.4 |
No |
0 |
| ESR1-009 |
ENSP00000384064
ENST00000406599
|
Q9H2M1 Show all »
« Hide
Q9H2M1 [Target identity:100%; Query identity:100%]Estrogen receptor; Estrogen receptor 1; Estrogen receptor alpha Q9UE35 [Target identity:34%; Query identity:100%]Estrogen receptor; Estrogen receptor 1; Estrogen receptor protein Q5T5H8 [Target identity:25%; Query identity:100%]Estrogen receptor; Estrogen receptor 1 Q9UBT1 [Target identity:6%; Query identity:100%]Estrogen receptor
|
Show »
« Hide
Transcription factors
|
Show »
« Hide
|
334 |
36.7 |
No |
0 |
| ESR1-010 |
ENSP00000401995
ENST00000415488
|
B0QYW7 Show all »
« Hide
B0QYW7 [Target identity:100%; Query identity:100%]Estrogen receptor; Estrogen receptor 1
|
Show »
« Hide
Potential transmembrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins
|
Show »
« Hide
|
107 |
12.3 |
No |
0 |
| ESR1-201 |
ENSP00000405330
ENST00000440973
|
P03372 Show all »
« Hide
P03372 [Direct mapping]Estrogen receptor G4XH65 [Target identity:100%; Query identity:100%]Estrogen nuclear receptor alpha E3WH18 [Target identity:31%; Query identity:100%]Estrogen receptor alpha Q9UE35 [Target identity:19%; Query identity:100%]Estrogen receptor; Estrogen receptor 1; Estrogen receptor protein Q5T5H8 [Target identity:14%; Query identity:100%]Estrogen receptor; Estrogen receptor 1 B6DU67 [Target identity:7%; Query identity:100%]Estrogen receptor alpha delta 3*,4,5,6,7*/775 hypothalamic isoform C7FFR5 [Target identity:7%; Query identity:100%]Estrogen receptor alpha 3*,4,5,6,7*/765 isoform C8CJL0 [Target identity:4%; Query identity:100%]Estrogen receptor alpha delta 2*,3,4,5,6,7 isoform Q9UBT1 [Target identity:3%; Query identity:100%]Estrogen receptor
|
Show »
« Hide
Candidate cancer biomarkers Transcription factors Potential transmembrane proteins THUMBUP predicted membrane proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level
|
Show »
« Hide
|
595 |
66.2 |
No |
0 |
| ESR1-202 |
ENSP00000387500
ENST00000443427
|
P03372 Show all »
« Hide
P03372 [Direct mapping]Estrogen receptor G4XH65 [Target identity:100%; Query identity:100%]Estrogen nuclear receptor alpha E3WH18 [Target identity:31%; Query identity:100%]Estrogen receptor alpha Q9UE35 [Target identity:19%; Query identity:100%]Estrogen receptor; Estrogen receptor 1; Estrogen receptor protein Q5T5H8 [Target identity:14%; Query identity:100%]Estrogen receptor; Estrogen receptor 1 B6DU67 [Target identity:7%; Query identity:100%]Estrogen receptor alpha delta 3*,4,5,6,7*/775 hypothalamic isoform C7FFR5 [Target identity:7%; Query identity:100%]Estrogen receptor alpha 3*,4,5,6,7*/765 isoform C8CJL0 [Target identity:4%; Query identity:100%]Estrogen receptor alpha delta 2*,3,4,5,6,7 isoform Q9UBT1 [Target identity:3%; Query identity:100%]Estrogen receptor
|
Show »
« Hide
Candidate cancer biomarkers Transcription factors Potential transmembrane proteins THUMBUP predicted membrane proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level
|
Show »
« Hide
|
595 |
66.2 |
No |
0 |
| ESR1-203 |
ENSP00000415934
ENST00000456483
|
P03372 Show all »
« Hide
P03372 [Direct mapping]Estrogen receptor E3WH18 [Target identity:39%; Query identity:100%]Estrogen receptor alpha Q9UE35 [Target identity:23%; Query identity:100%]Estrogen receptor; Estrogen receptor 1; Estrogen receptor protein B0QYW7 [Target identity:22%; Query identity:100%]Estrogen receptor; Estrogen receptor 1 Q5T5H8 [Target identity:17%; Query identity:100%]Estrogen receptor; Estrogen receptor 1 C7FFR5 [Target identity:9%; Query identity:100%]Estrogen receptor alpha 3*,4,5,6,7*/765 isoform B6DU67 [Target identity:8%; Query identity:100%]Estrogen receptor alpha delta 3*,4,5,6,7*/775 hypothalamic isoform C8CJL0 [Target identity:4%; Query identity:100%]Estrogen receptor alpha delta 2*,3,4,5,6,7 isoform Q9UBT1 [Target identity:4%; Query identity:100%]Estrogen receptor
|
Show »
« Hide
Candidate cancer biomarkers Transcription factors Potential transmembrane proteins THUMBUP predicted membrane proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level
|
Show »
« Hide
|
483 |
53.7 |
No |
0 |
| ESR1-204 |
ENSP00000445454
ENST00000544394
|
F6SD09 Show all »
« Hide
F6SD09 [Target identity:100%; Query identity:100%]Estrogen receptor C7FFR5 [Target identity:14%; Query identity:100%]Estrogen receptor alpha 3*,4,5,6,7*/765 isoform B6DU67 [Target identity:13%; Query identity:100%]Estrogen receptor alpha delta 3*,4,5,6,7*/775 hypothalamic isoform
|
Show »
« Hide
Transcription factors Potential transmembrane proteins THUMBUP predicted membrane proteins
|
Show »
« Hide
|
310 |
35.3 |
No |
0 |
|
|
|
|
|
|