CMA1

GENE INFORMATION

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Gene name

CMA1

Synonyms

Description

chymase 1, mast cell (HGNC Symbol)

Entrez gene summary

This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases. [provided by RefSeq, Jul 2008]

Chromosome

14 (Chromosome progress)

Cytoband

q12

Chromosome location (bp)

24974559 - 24977471

Ensembl

ENSG00000092009 (version 73.37)

Entrez gene

1215

UniProt

P23946 (UniProt - Evidence at protein level)

neXtProt

NX_P23946

Antibodypedia

CMA1 antibodies
 

PROTEIN VIEW

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CMA1-001
 
CMA1-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CMA1-001 ENSP00000250378
ENST00000250378
P23946
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Show » Show » 247 27.3 Yes 0
CMA1-002 ENSP00000206446
ENST00000206446
Q3SY37
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Show » 136 14.9 No 0