MYH7

GENE INFORMATION

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Gene name

MYH7 (HGNC Symbol)

Synonyms

CMD1S, CMH1, MPD1

Description

myosin, heavy chain 7, cardiac muscle, beta (HGNC Symbol)

Entrez gene summary

Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy. [provided by RefSeq, Jul 2008]

Chromosome

14 (Chromosome progress)

Cytoband

q11.2

Chromosome location (bp)

23881947 - 23904927

Ensembl

ENSG00000092054 (version 73.37)

Entrez gene

4625

UniProt

P12883 (UniProt - Evidence at protein level)

neXtProt

NX_P12883

Antibodypedia

MYH7 antibodies
 

PROTEIN VIEW

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MYH7-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MYH7-001 ENSP00000347507
ENST00000355349
P12883
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