CDC45

GENERAL INFORMATION

? »

Gene name

CDC45

Gene description

Cell division cycle 45

Protein class

Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Tissue enhanced (testis)
GTEx:Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein localization

Nuclear expression in most tissues. Highest expression testicular seminiferus duct cells.

ANTIBODY RELIABILITY

? »

Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA000614 , CAB009459
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Tissue enhanced (testis)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (testis)

Organ

Expression



GENE INFORMATION

? »

Gene name

CDC45 (HGNC Symbol)

Synonyms

CDC45L, CDC45L2

Description

Cell division cycle 45 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Chromosome

22

Cytoband

q11.21

Chromosome location (bp)

19479459 - 19520612

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000093009 (version 78.38)

Entrez gene

8318

UniProt

O75419 (UniProt - Evidence at protein level)

neXtProt

NX_O75419

Antibodypedia

CDC45 antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000263201
 
ENST00000404724
 
ENST00000407835
 
ENST00000437685
 
ENST00000438587
 
ENST00000455750
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDC45-001 ENSP00000385240
ENST00000407835
O75419
Show all »
Show » Show » 566 65.6 No 0
CDC45-002 ENSP00000384978
ENST00000404724
O75419
Show all »
Show » Show » 520 60.2 No 0
CDC45-003 ENSP00000397434
ENST00000438587
C9J911
Show all »
Show » Show » 159 18.5 Yes 0
CDC45-004 ENSP00000413138
ENST00000455750
C9K087
Show all »
Show » Show » 112 13 No 0
CDC45-201 ENSP00000263201
ENST00000263201
O75419
Show all »
Show » Show » 566 65.6 No 0
CDC45-202 ENSP00000405726
ENST00000437685
O75419
Show all »
Show » Show » 598 68.8 No 0