MAP3K1

GENERAL INFORMATION

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Gene name

MAP3K1

Gene description

Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase

Protein class

Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
CAB004500
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

MAP3K1 (HGNC Symbol)

Synonyms

MAPKKK1, MEKK, MEKK1

Description

Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012]

Chromosome

5

Cytoband

q11.2

Chromosome location (bp)

56815574 - 56896152

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000095015 (version 78.38)

Entrez gene

4214

UniProt

Q13233 (UniProt - Evidence at protein level)

neXtProt

NX_Q13233

Antibodypedia

MAP3K1 antibodies


PROTEIN BROWSER

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ENST00000399503
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAP3K1-001 ENSP00000382423
ENST00000399503
Q13233
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